Practice
Open Access
International normalized ratio and activated partial thromboplastin time testing
Nicholas L. J. Chornenki, Michael Fralick and Michelle Sholzberg
CMAJ August 29, 2022 194 (33) E1135; DOI: https://doi.org/10.1503/cmaj.220629
Nicholas L. J. Chornenki
Department of Medicine (Chornenki), Queen’s University, Kingston, Ont.; Division of General Internal Medicine (Fralick), Sinai Health, and Departments of Medicine, and Laboratory Medicine and Pathobiology (Sholzberg), St Michael’s Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ont.
MDMichael Fralick
Department of Medicine (Chornenki), Queen’s University, Kingston, Ont.; Division of General Internal Medicine (Fralick), Sinai Health, and Departments of Medicine, and Laboratory Medicine and Pathobiology (Sholzberg), St Michael’s Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ont.
MD PhDMichelle Sholzberg
Department of Medicine (Chornenki), Queen’s University, Kingston, Ont.; Division of General Internal Medicine (Fralick), Sinai Health, and Departments of Medicine, and Laboratory Medicine and Pathobiology (Sholzberg), St Michael’s Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ont.
MDCM MScData supplements
Online appendix
Related Articles
- Laupacis, A. (2022). “I thought everybody bled like that”: a patient’s experience with von Willebrand disease. CMAJ, 194(33), E1137. Accessed May 13, 2024. https://doi.org/10.1503/cmaj.221102.
- Chornenki, N. L., Fralick, M., & Sholzberg, M. (2022). Tests de dépistage du rapport international normalisé et du temps de céphaline activée. CMAJ, 194(43), E1491-E1492. Accessed May 13, 2024. https://doi.org/10.1503/cmaj.220629-f.
In this issue
Article extras
Article tools
Respond to this article
International normalized ratio and activated partial thromboplastin time testing
Nicholas L. J. Chornenki, Michael Fralick, Michelle Sholzberg
CMAJ Aug 2022, 194 (33) E1135; DOI: 10.1503/cmaj.220629
Jump to section
- Article
- International normalized ratio (INR) and activated partial thromboplastin time (aPTT) have limited clinical utility
- Bleeding history is the most important predictor of an inherited bleeding disorder
- International normalized ratio and aPTT testing are not indicated before low-risk surgery or interventional radiology
- An abnormal INR or aPTT in a patient who is bleeding suggests a potential medical emergency
- Clinical history and drug pharmacokinetics are more important than INR or aPTT results in guiding clinical decision-making in patients taking direct oral anticoagulants (DOACs)
- Footnotes
- References
- Figures & Tables
- Related Content
- Responses
- Metrics
Related Articles
Cited By...
- No citing articles found.