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The challenges of determining noninferiority margins: a case study of noninferiority randomized controlled trials of novel oral anticoagulants
Grace Wangge, Kit C.B. Roes, Anthonius de Boer, Arno W. Hoes and Mirjam J. Knol
CMAJ February 19, 2013 185 (3) 222-227; DOI: https://doi.org/10.1503/cmaj.120142
Grace Wangge
From the Division of Pharmacoepidemiology and Clinical Pharmacology (Wangge, de Boer, Knol), Utrecht Institute for Pharmaceutical Sciences, Utrecht University; and Julius Centre for Health Sciences and Primary Care (Roes, Hoes, Knol), University Medical Centre Utrecht, Utrecht, the Netherlands
MD MScKit C.B. Roes
From the Division of Pharmacoepidemiology and Clinical Pharmacology (Wangge, de Boer, Knol), Utrecht Institute for Pharmaceutical Sciences, Utrecht University; and Julius Centre for Health Sciences and Primary Care (Roes, Hoes, Knol), University Medical Centre Utrecht, Utrecht, the Netherlands
PhDAnthonius de Boer
From the Division of Pharmacoepidemiology and Clinical Pharmacology (Wangge, de Boer, Knol), Utrecht Institute for Pharmaceutical Sciences, Utrecht University; and Julius Centre for Health Sciences and Primary Care (Roes, Hoes, Knol), University Medical Centre Utrecht, Utrecht, the Netherlands
MD PhDArno W. Hoes
From the Division of Pharmacoepidemiology and Clinical Pharmacology (Wangge, de Boer, Knol), Utrecht Institute for Pharmaceutical Sciences, Utrecht University; and Julius Centre for Health Sciences and Primary Care (Roes, Hoes, Knol), University Medical Centre Utrecht, Utrecht, the Netherlands
MD PhDMirjam J. Knol
From the Division of Pharmacoepidemiology and Clinical Pharmacology (Wangge, de Boer, Knol), Utrecht Institute for Pharmaceutical Sciences, Utrecht University; and Julius Centre for Health Sciences and Primary Care (Roes, Hoes, Knol), University Medical Centre Utrecht, Utrecht, the Netherlands
PhD
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The challenges of determining noninferiority margins: a case study of noninferiority randomized controlled trials of novel oral anticoagulants
Grace Wangge, Kit C.B. Roes, Anthonius de Boer, Arno W. Hoes, Mirjam J. Knol
CMAJ Feb 2013, 185 (3) 222-227; DOI: 10.1503/cmaj.120142
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