CMAJ • November 20, 2007; 177 (11). doi:10.1503/cmaj.070627.
© 2007 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
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Review

Treatment of tobacco dependence: integrating recent progress into practice

Bernard Le Foll, MD PhD and Tony P. George, MD

From the Translational Addiction Research Laboratory (Le Foll) and Addiction Psychiatry (George), Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont.

Correspondence to: Dr. Bernard Le Foll, Head, Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell St., Toronto ON M5S 2S1; fax 416 595-6922; bernard_lefoll{at}camh.net

Abstract

Tobacco use is one of the leading preventable causes of death in developed countries. Adoption of approaches that have demonstrated efficacy to improve the treatment of tobacco dependence are critical to reduce the health consequences of tobacco use. We summarize the latest epidemiologic data on tobacco use, the mechanisms that underlie tobacco dependence, and advances in pharmacotherapy and nonpharmacologic interventions available for the treatment of tobacco dependence. Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings.




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