PT  - JOURNAL ARTICLE
AU  - Bernard Le Foll, MD PhD
AU  - Tony P. George MD
TI  - Treatment of tobacco dependence: integrating recent progress into practice
AID  - 10.1503/cmaj.070627
DP  - 2007 Nov 20
TA  - Canadian Medical Association Journal
PG  - 1373--1380
VI  - 177
IP  - 11
4099  - http://www.cmaj.ca/content/177/11/1373.short
4100  - http://www.cmaj.ca/content/177/11/1373.full
SO  - CMAJ2007 Nov 20; 177
AB  - Tobacco use is one of the leading preventable causes of death in developed countries. Adoption of approaches that have demonstrated efficacy to improve the treatment of tobacco dependence are critical to reduce the health consequences of tobacco use. We summarize the latest epidemiologic data on tobacco use, the mechanisms that underlie tobacco dependence, and advances in pharmacotherapy and nonpharmacologic interventions available for the treatment of tobacco dependence. Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings.