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Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults

Jared Bullard, Duane Funk, Kerry Dust, Lauren Garnett, Kaylie Tran, Alex Bello, James E. Strong, Santina J. Lee, Jillian Waruk, Adam Hedley, David Alexander, Paul Van Caeseele, Carla Loeppky and Guillaume Poliquin
CMAJ April 26, 2021 193 (17) E601-E606; DOI: https://doi.org/10.1503/cmaj.210263
Jared Bullard
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Duane Funk
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Kerry Dust
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Lauren Garnett
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Kaylie Tran
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Alex Bello
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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James E. Strong
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Santina J. Lee
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Jillian Waruk
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Adam Hedley
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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David Alexander
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Paul Van Caeseele
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Carla Loeppky
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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Guillaume Poliquin
Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.
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  • RE: The Role of Pediatric Age Groups in the Spread of COVID-19
    Nevio Cimolai [MD,FRCP(C)]
    Posted on: 13 April 2021
  • Posted on: (13 April 2021)
    Page navigation anchor for RE: The Role of Pediatric Age Groups in the Spread of COVID-19
    RE: The Role of Pediatric Age Groups in the Spread of COVID-19
    • Nevio Cimolai [MD,FRCP(C)], Physician, Faculty of Medicine, The University of British Columbia and Children's and Women's Health Centre of British Columbia

    Bullard et al. in the Journal suggest that the role of pediatric age groups in SARS-CoV-2 transmission has been unclear and that their study finds that children are not the main vectors for spread.(1) Whereas it may be true that pediatric age groups have not been the main foci for COVID-19, the simple finding of lesser live virus quantitations in respiratory specimens does not sufficiently provide evidence of the latter. Undoubtedly most feel compelled to mitigate the role of children in SARS-CoV-2 transmission as there has been an inherent belief that closure of schools has considerable risk for societal disruption and harm to the young individual. Being partial to the attempts to minimize the impact of COVID-19 on our youth is a worthy position, but the reality of common respiratory virus transmission has been firmly understood including that of endemic respiratory coronaviruses otherwise.
    Elsewhere in the world, school re-openings have been linked to resurgences.(1) Even in Canada, there are ample citations near weekly where some schools have been considerably impacted. School transmission is inevitably linked to teacher risk and to other associated family risk.(2) Whereas the younger school ages may be less implicated, there is a probable age-dependent stratification by which those in high schools eventually have risk that is similar to adult populations elsewhere.(3) Apart from practical experience with these risks and consequences, modelling studies also give...

    Show More

    Bullard et al. in the Journal suggest that the role of pediatric age groups in SARS-CoV-2 transmission has been unclear and that their study finds that children are not the main vectors for spread.(1) Whereas it may be true that pediatric age groups have not been the main foci for COVID-19, the simple finding of lesser live virus quantitations in respiratory specimens does not sufficiently provide evidence of the latter. Undoubtedly most feel compelled to mitigate the role of children in SARS-CoV-2 transmission as there has been an inherent belief that closure of schools has considerable risk for societal disruption and harm to the young individual. Being partial to the attempts to minimize the impact of COVID-19 on our youth is a worthy position, but the reality of common respiratory virus transmission has been firmly understood including that of endemic respiratory coronaviruses otherwise.
    Elsewhere in the world, school re-openings have been linked to resurgences.(1) Even in Canada, there are ample citations near weekly where some schools have been considerably impacted. School transmission is inevitably linked to teacher risk and to other associated family risk.(2) Whereas the younger school ages may be less implicated, there is a probable age-dependent stratification by which those in high schools eventually have risk that is similar to adult populations elsewhere.(3) Apart from practical experience with these risks and consequences, modelling studies also give reason to believe that schools can have a considerable impact on transmission and eventual disease burden.(4) In looking at the big picture, it is behaviour that drives transmission more than purely age or school status.(5)
    In the summer of 2020 nearing school entry, it was clear that many school districts were not sufficiently prepared for what was to come. In the flurry of COVID-19 activity otherwise, proportionately less dedication was given to teachers, youth, and their families. There evolved an inherent inconsistency in masking and other mitigation strategies. Many were left unknowing of the expected standards. For the number of individuals involved in co-ordinating education Canada-wide, there is ample opportunity for great minds to think alike in providing the best compromise for teaching while maintaining high standards for prevention. As vaccines mitigate disease for older ages to begin, the shift will inevitably occur towards a proportionately higher burden of infection among younger populations. The potential role of youth in SARS-CoV-2 transmission would have been well-known even before the epidemic began. It is now time to focus intensively on how to realistically minimize spread in schools here forward and to safeguard both youth and their contacts.

    Show Less
    Competing Interests: None declared.

    References

    • 1. Cassini L, Roccetti M. Reopening Italy’s schools in September 2020: a Bayesian estimation of the change in the growth rate of new SARS-CoV-2 cases. medRxiv Apr 6. doi: 10.1101/2021.04.08.21254993
    • 2. Vlachos J, Hertegãrd E, Svaleryd HB. The effects of school closures on SARS-CoV-2 among parents and teachers. Proc Natl Acad Sci USA 2021;118(9):e2020834118.
    • 3. Gras-Le-Guen C, Cohen R, Rozenberg J, Launay E, Levy-Bruhl D, Delacourt C. Reopening schools in the context of increasing COVID-19 community transmission: the French experience. Arch Pediatr 2021;28(3):178-185.
    • 4. Munday JD, Sherratt K, Meakin S, et al. Implications of the school-household network structure on SARS-CoV-2 transmission under school reopening strategies in England. Nat Commun 2021;12(1):1942.
    • 5. Zimmerman FJ, Anderson NW. Association of the timing of school closings and behavioural changes with the evolution of the Coronavirus Disease 2019 pandemic in the US. JAMA Pediatr 2021 Feb 22;e206371. doi: 10.1001/jamapediatrics.2020.6371
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Canadian Medical Association Journal: 193 (17)
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Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults
Jared Bullard, Duane Funk, Kerry Dust, Lauren Garnett, Kaylie Tran, Alex Bello, James E. Strong, Santina J. Lee, Jillian Waruk, Adam Hedley, David Alexander, Paul Van Caeseele, Carla Loeppky, Guillaume Poliquin
CMAJ Apr 2021, 193 (17) E601-E606; DOI: 10.1503/cmaj.210263

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Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults
Jared Bullard, Duane Funk, Kerry Dust, Lauren Garnett, Kaylie Tran, Alex Bello, James E. Strong, Santina J. Lee, Jillian Waruk, Adam Hedley, David Alexander, Paul Van Caeseele, Carla Loeppky, Guillaume Poliquin
CMAJ Apr 2021, 193 (17) E601-E606; DOI: 10.1503/cmaj.210263
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