Research
Resting heart rate, heart rate variability and functional decline in old age
Giulia Ogliari, Simin Mahinrad, David J. Stott, J. Wouter Jukema, Simon P. Mooijaart, Peter W. Macfarlane, Elaine N. Clark, Patricia M. Kearney, Rudi G.J. Westendorp, Anton J. M. de Craen and Behnam Sabayan
CMAJ October 20, 2015 187 (15) E442-E449; DOI: https://doi.org/10.1503/cmaj.150462
Giulia Ogliari
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MDSimin Mahinrad
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD MScDavid J. Stott
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDJ. Wouter Jukema
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDSimon P. Mooijaart
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDPeter W. Macfarlane
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDElaine N. Clark
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MAPatricia M. Kearney
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDRudi G.J. Westendorp
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDAnton J. M. de Craen
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
PhDBehnam Sabayan
Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands
MD PhDData supplements
Online Appendices
- Appendix 1: Characteristics of study population in tertiles of resting heart rate
- Appendix 10: Baseline functional status in tertiles of standardized SDNN
- Appendix 11: Risk of decline in functional status in tertiles of standardized SDNN
- Appendix 12: Risk of decline in functional status in groups of resting heart rate
- Appendix 2: Characteristics of study population in tertiles of SDNN
- Appendix 3: Risk of decline in functional status in tertiles of resting heart rate and SDNN in the minimally adjusted models
- Appendix 4: Risk of decline in functional status in tertiles of resting heart rate and SDNN after exclusion of participants with incident non-fatal stroke during follow-up
- Appendix 5: Risk of decline in functional status in tertiles of resting heart rate and SDNN after exclusion of participants with incident coronary events during follow-up
- Appendix 6: Risk of decline in functional status in tertiles of resting heart rate and SDNN after exclusion of participants with incident heart failure hospitalization during follow-up
- Appendix 7: Risk of decline in functional status in tertiles of resting heart rate and SDNN after inclusion of participants with maximum functional status at baseline
- Appendix 8: Risk of decline in functional status in tertiles of resting heart rate and SDNN after inclusion of participants who completed 36 months of follow-up
- Appendix 9: Risk of functional decline in relation to heart rate in stratified analyses
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Resting heart rate, heart rate variability and functional decline in old age
Giulia Ogliari, Simin Mahinrad, David J. Stott, J. Wouter Jukema, Simon P. Mooijaart, Peter W. Macfarlane, Elaine N. Clark, Patricia M. Kearney, Rudi G.J. Westendorp, Anton J. M. de Craen, Behnam Sabayan
CMAJ Oct 2015, 187 (15) E442-E449; DOI: 10.1503/cmaj.150462
Resting heart rate, heart rate variability and functional decline in old age
Giulia Ogliari, Simin Mahinrad, David J. Stott, J. Wouter Jukema, Simon P. Mooijaart, Peter W. Macfarlane, Elaine N. Clark, Patricia M. Kearney, Rudi G.J. Westendorp, Anton J. M. de Craen, Behnam Sabayan
CMAJ Oct 2015, 187 (15) E442-E449; DOI: 10.1503/cmaj.150462