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Letters

Cobalamin deficiency in elderly patients

S. Peter Wetterberg
CMAJ February 15, 2005 172 (4) 450; DOI: https://doi.org/10.1503/cmaj.1041367
S. Peter Wetterberg
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  • © 2005 Canadian Medical Association or its licensors

Emmanuel Andrès and colleagues1 state that the classic treatment for deficiency of vitamin B12 is injections of crystalline vitamin B12 and that an oral treatment has “recently” been devised. However, oral treatment of pernicious anemia was described in 1926 by George Minot and William Murphy.2 Indeed, in 1934, they (along with George Whipple) received the Nobel Prize for this work. Not until 1948 did Karl Folkers and his coworkers at Merck succeed in purifying crystalline vitamin B12.3

Footnotes

  • Competing interests: None declared.

References

  1. 1.↵
    Andrès E, Loukili NH, Noel E, Kaltenbach G, Ben Abdelgheni M, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004;171(3):251-9.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    Minot ER, Murphy WP. Treatment of pernicious anemia by a special diet. JAMA 1926;87: 470-6.
    OpenUrlCrossRef
  3. 3.↵
    Rick EL, Brink NG, Koniuszy FR, Wood TR, Folkers K. Crystalline vitamin B12. Science 1948; 107:396-8.
    OpenUrlFREE Full Text
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Canadian Medical Association Journal: 172 (4)
CMAJ
Vol. 172, Issue 4
15 Feb 2005
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Cobalamin deficiency in elderly patients
S. Peter Wetterberg
CMAJ Feb 2005, 172 (4) 450; DOI: 10.1503/cmaj.1041367

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Cobalamin deficiency in elderly patients
S. Peter Wetterberg
CMAJ Feb 2005, 172 (4) 450; DOI: 10.1503/cmaj.1041367
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