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CMAJ • April 15, 2003; 168 (8)
© 2003 Canadian Medical Association or its licensors

Review
Synthèse

Risks and benefits of hormone replacement therapy: The evidence speaks

Karin H. Humphries and Sabrina Gill

From the Division of Cardiology (Humphries) and the Division of Endocrinology and Metabolism (Gill), Department of Medicine, St. Paul's Hospital, University of British Columbia and Centre for Health Evaluation & Outcome Sciences, Vancouver, BC.

Correspondence to: Dr. Sabrina Gill, Division of Endocrinology and Metabolism, St. Paul's Hospital, Rm. 467, Comox Building, 1081 Burrard St., Vancouver BC V6Z 1Y6; fax 604 806-8594; sgill{at}providencehealth.bc.ca

Abstract

UNTIL RECENTLY, OBSERVATIONAL STUDIES suggested a decreased risk of cardiovascular disease, osteoporotic fractures, cognitive decline and colon cancer with the use of hormone replacement therapy (HRT). Recent randomized controlled trials have failed to show a protective effect of HRT in reducing the risk of coronary artery disease and instead have revealed an increased risk of heart disease, stroke, invasive breast cancer and venous thromboembolism, but a decreased risk of colorectal cancer and osteoporotic fractures. In this article we review the current evidence of the risks and benefits of HRT.


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CMAJ, 17 Nov 2003 [Full text]