- © 2004 Canadian Medical Association or its licensors
We welcome the opportunity to restate important limitations of our study, which we discuss in our paper.1 Frank Leung's main concern relates to sample size and its implications. The sample size of 16 for a power of 80% was calculated using an estimated standard deviation of 2.0 and an estimated mean difference of 1.5 cm on a 10-cm visual analogue scale. This mean difference was considered adequate in the expected and confirmed sample of moderately hungover individuals.2 Because of the small sample size and the measurement variation, which proved larger than expected, we discuss in our paper the degree of uncertainty relating to the data and state that this might have obscured a possible true effect. Acknowledging the study's limitations and in the absence of any trend in favour of artichoke extract, we stand by our conclusion that “our findings do not suggest that artichoke extract is effective in preventing alcohol-induced hangover.”
Max H. Pittler Edzard Ernst Complementary Medicine Peninsula Medical School Universities of Exeter and Plymouth Exeter, UK