Summary
Trichomonacidum Metronidazole in daily doses of 600 and 800 mg/kg was applicated per throat-sound to six week old SPF-Wistar-rats each day for six weeks.
Increase of body-weight, food-demand and the usual clinical watch-over showed no difference to controll-group.
Already three days after begin of application behaviour-research showed motion-changes, especially balance-disturbance of femal rats. Measure of running-speed proved no changes.
Histological sections of the perfused CNS after treatment with 800 mg/kg Metronidazole showed relatively sharp bounded, usually symetric lesions in the nuclei vestibularis and cochlearis, in the nuclei of the cerebellar roof, paramedial in the colliculus anterior and in the superior olive.
These alterations are qualitatively and topographically comparable to CNS-lesions in rats caused by B1-avitaminosis and lesions seen in Wernicke's-encephalopathy in adults and children.
The initial and progressed stages of such an experimental CNS insult in rats open numerous possibilities to clear up the pathogenesis of this and other spongiform dystrophies.
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v Rogulja, P., Kovac, W. & Schmid, H. Metronidazol-Encephalopathie der Ratte. Acta Neuropathol 25, 36–45 (1973). https://doi.org/10.1007/BF00686856
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DOI: https://doi.org/10.1007/BF00686856