Abstract Dr. Thomas Chalmers, an American physician who played a pivotal role in the
scientific development of the randomized control trial and meta-analysis, died late last year …

Abstract Dr. Thomas Chalmers, an American physician who played a pivotal role in the
scientific development of the randomized control trial and meta-analysis, died late last year …

Dr. Tom Chalmers, 1917-1995: the tribulations ofa tralist Page 1 Dr. Tom Chalmers, 1917-1995:
the tribulations ofa tralist Malcolm Maclure, ScD …

I am honored to be invited to speak to the Society for Clinical Trials. It is not often that one is
given the privilege to talk to a group whose origins extend so far back in time. Your founder …

Few people have contributed as much as Thomas (Tom) Chalmers to the fair assessment of
treatment effects. His research was wide ranging, including both the randomised …

Randomized clinical trials play a pivotal role in answering questions about the superiority of
competing treatments. They are initiated not because a particular investigator is unsure of …

Sir Austin Bradford Hill, who died on April 18, 1991 at age 93, was described in the London
Daily Telegraph as" the most relentless statistician of the century." The Guardian noted that …

Abstract Born in 1917 in Forest Hills, NY; died in 1995 in Hanover, NH. Chalmers was a
leader in the design, conduct, and evaluation of clinical trials, favoring randomized …

Randomized controlled trials are such a fixture of clinical research that it seems hard to
believe that it hasn't always been that way. Actually, however, evaluations of health care …

Many medical investigators now think that prospective randomized clinical trials offer the
most reliable way of comparing alternative treatments. Although the concepts of randomized …