992 JAMC• 17 OCT. 2000; 163 (8) plasma clotting cascade will rapidly promote thrombin
formation and fibrin deposition. Almost simultaneously, reactions are set in motion to limit the …

The first families with a tendency to venous thrombosis were reported in the early 1900s (1).
In 1965, Egeberg reported a family with thrombophilia and an identified hereditary defect …

The coagulation system is governed by a subtle balance between clotting activators and
inhibitors. Many genes can contribute to the overall phenotype, and polymorphisms may act …

Venous thromboembolism, which includes deep vein thrombosis and pulmonary embolism,
is the result of an imbalance among procoagulant, anticoagulant and profibrinolytic …

Unlike the deficiencies of the anticoagulant proteins antithrombin, protein C and S, rare in
patients with venous thromboembolism (VTE; 5% altogether) and in the general population …

About half of all episodes of venous thromboembolism (VTE, ie deep vein thrombosis and
pulmonary embolism) are elicited by an acquired clinical risk factor, such as recent surgery …

The concept of multiple risk factors interacting to cause arterial thrombotic disease is well
established. Conversely, venous thrombotic events are often described as discrete events …

Venous thromboembolism is a serious disorder because of its potential complications, such
as pulmonary embolism and the post-thrombotic syndrome. Inherited determinants of …

BACKGROUND AND OBJECTIVES: The clinical expression of factor V Leiden varies widely
within and between families and only a minority of carriers will ever develop venous …

A thrombophilic disorder is a hereditary or acquired condition that increases the risk of
thrombosis. The most common hereditary thrombophilias that predispose to venous …