[HTML][HTML] Intravenously administered vitamin C as cancer therapy: three cases

SJ Padayatty, HD Riordan, SM Hewitt, A Katz, LJ Hoffer… - Cmaj, 2006 - Can Med Assoc
Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes,
may improve symptoms and prolong life in patients with terminal cancer. Double-blind …

Review of high‐dose intravenous vitamin C as an anticancer agent

MK Wilson, BC Baguley, C Wall… - Asia‐Pacific Journal …, 2014 - Wiley Online Library
In the 1970s, P auling and C ameron reported increased survival of patients with advanced
cancer treated with high‐dose intravenous (IV) vitamin C (L‐ascorbate, ascorbic acid) …

Intravenous vitamin C and cancer: a systematic review

H Fritz, G Flower, L Weeks, K Cooley… - Integrative cancer …, 2014 - journals.sagepub.com
Background. Intravenous vitamin C (IVC) is a contentious adjunctive cancer therapy, widely
used in naturopathic and integrative oncology settings. We conducted a systematic review of …

The controversial place of vitamin C in cancer treatment

J Verrax, PB Calderon - biochemical pharmacology, 2008 - Elsevier
In 2008, we celebrate the 80th anniversary of the discovery of vitamin C. Since then, we
know that vitamin C possesses few pharmacological actions although it is still perceived by …

[HTML][HTML] High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a phase I-II clinical trial

LJ Hoffer, L Robitaille, R Zakarian, D Melnychuk… - PloS one, 2015 - journals.plos.org
Background Biological and some clinical evidence suggest that high-dose intravenous
vitamin C (IVC) could increase the effectiveness of cancer chemotherapy. IVC is widely used …

Vitamin C pharmacokinetics: implications for oral and intravenous use

SJ Padayatty, H Sun, Y Wang, HD Riordan… - Annals of internal …, 2004 - acpjournals.org
Background: Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical
studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double …

[HTML][HTML] Intravenous vitamin C for cancer therapy–identifying the current gaps in our knowledge

AC Carr, J Cook - Frontiers in physiology, 2018 - frontiersin.org
The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense
controversy. Despite this, high dose IVC has been administered for decades by …

[HTML][HTML] High-dose vitamin C for cancer therapy

A Mussa, RA Mohd Idris, N Ahmed, S Ahmad… - Pharmaceuticals, 2022 - mdpi.com
In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …

[HTML][HTML] High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach

E Klimant, H Wright, D Rubin, D Seely, M Markman - Current oncology, 2018 - mdpi.com
This article reviews intravenous vitamin C (IV C) in cancer care and offers a rational
approach to enable medical oncologists and integrative practitioners to safely provide IV C …