Figure 1: Electroencephalogram taken on day 1 after the patient was admitted to hospital for
the treatment of valproate-related hyperammonemic encephalopathy. Note the diffuse high …

Hyperammonemic encephalopathy rarely occurs when valproate is used alone. Underlying
urea cycle enzyme deficiencies, concomitant drugs like salicylates, topiramate, underlying …

Hyperammonemic encephalopathy secondary to the use of valproate is rare without
evidence of hepatotoxicity, and it usually presents with confusion, agitation, irritability …

Background Valproic acid may induce hyperammonemic encephalopathy. Various
electroencephalogram (EEG) abnormalities have been documented in association with this …

A 56-year-old Caucasian male with a history of seizure disorder on long-term prophylaxis
with valproate presented with altered mental status, aggressive behavior, decreased oral …

Background Hyperammonemic encephalopathy is a rare and serious adverse reaction to
valproate. Although there is documentation of this reaction in previous reports, very little is …

Discussion. Encephalopathy and elevated levels of serum ammonia is often attributed to
liver failure. However, other conditions, including valproate-related hyperammonemic …

A 21-year-old male known case of primary hypothyroidism, Seizure disorder sequelae of an
old trauma receiving sodium valproate, clobazam and phenobarbitone for control of …

A 59-year-old man with a background of poststroke epilepsy, lung cancer, chronic
obstructive pulmonary disease and hypertension, presented to the medical assessment unit …

Valproate is a drug commonly prescribed in neurology and psychiatry. Hyperammonemic
encephalopathy due to valproate is a severe complication. A 44-year-old man with a past …