Mv j'edical therapeutics has become an increasingly complex subject for physicians and
pharmacists. The fact that some new agentshave similar-sounding names is of major …

The intense research effort to develop molecules with the ability to inhibit the replication of
human immunodeficiency virus type 1 was greatly facilitated by the elucidation of the viral …

We conducted a double-blind, placebo-controlled trial of oral azidothymidine (AZT) in 282
patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex …

AN ADVISORY COMMITTEE of the Food and Drug Administration (FDA), by a vote of ten to
one, has recommended that the FDA commissioner approve the anti-viral drug …

Abstract To the Editor: Richman et al., in reviewing the experience of the AZT Collaborative
Working Group on the toxicity of azidothymidine (zidovudine [Retrovir], or AZT) in the July 23 …

Excerpt Since it was originally described in 1981, the acquired immunodeficiency syndrome
(AIDS) has been a complex therapeutic challenge. In 1983, the discovery of human …

Four patients with the acquired immunodeficiency syndrome, and a history of Pneumocystis
carinii pneumonia developed severe pancytopenia (hemoglobin,< 85 g/L; granulocytes,≤ …

The first phase in the history of the chemotherapy of infection by HIV has been completed.
An effective compound, AZT, has been identified that prolongs life and reduces morbidity …

Excerpt Zidovudine (also known as azidothymidine or AZT) is a 2′, 3′-dideoxynucleoside
analogue with antiviral activity against the human immunodeficiency virus (HIV). Preclinical …

To the Editor: A 38-year-old black male homosexual in an advanced stage of the acquired
immunodeficiency syndrome had fever, diarrhea, and thrush from 1983 to 1986; in April …