© 2012 Canadian Medical Association or its licensors CMAJ, August 7, 2012, 184 (11) 1257
postsynaptic glutamate receptors triggers a complex chain of intracellular events resulting in …

Trauma to the developing brain constitutes an unexplored field. The few studies attempting
to model and study paediatric head trauma, the leading cause of death and disability in the …

Acquired brain injuries represent a major cause of disability in the pediatric population.
Understanding responses to developmental acquired brain injuries requires knowledge of …

Perinatal brain injury following trauma, hypoxia, and/or ischemia represents a substantial
cause of pediatric disabilities including mental retardation. Such injuries lead to neuronal …

Plasticity is an intrinsic property of the central nervous system, reflecting its capacity to
respond in a dynamic manner to the environment and experience via modification of neural …

In this review, five questions serve as the framework to discuss the importance of age-
related differences in the pathophysiology and therapy of traumatic brain injury (TBI). The …

Knowledge of the molecular mechanisms that underlie neuron death following stroke is
important to allow the development of effective neuroprotective strategies. Since studies in …

The effect of age at injury on outcome after acquired brain injury (ABI) has been the subject
of much debate. Many argue that young brains are relatively tolerant of injury. A contrasting …

Traumatic brain injury (TBI) is a major cause of death and disability in children. Severe TBI is
a leading cause of death and often leads to life changing disabilities in survivors. The …

Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and
mortality in children. Experimental and clinical studies demonstrate that the developmental …