A preventable teratology: isotretinoin

RD Wilson - CMAJ, 2016 - Can Med Assoc
It was concerning to read Henry and colleagues' study on the poor adherence to pregnancy
prevention while women are taking isotretinoin. 1 This drug was first licensed in 1982 in the …

A survey of pregnant women using isotretinoin

J Robertson, JE Polifka, M Avner… - … Research Part A …, 2005 - Wiley Online Library
BACKGROUND Isotretinoin is a known human teratogen, causing birth defects and/or
subnormal cognitive performance in prenatally‐exposed children. METHODS A survey was …

[HTML][HTML] Generic isotretinoin: a new risk for unborn children

G Koren, M Avner, N Shear - CMAJ, 2004 - Can Med Assoc
Information Services had the labelled indication. Moreover, although the drug was originally
intended to be prescribed by dermatologists, many family physicians now prescribe it. Of the …

[HTML][HTML] A multicenter cohort study evaluating the teratogenic effects of isotretinoin on neonates

P Brzezinski, GI Zonda, MA Hincu, IA Vasilache… - Children, 2022 - mdpi.com
(1) Background: Isotretinoin (ISO) is a systemic retinoid known for its teratogenic effects on
embryos and fetuses. The aim of this study was to compare the pregnancy outcomes of …

Pregnancy outcomes and factors associated with voluntary pregnancy termination in women who had been treated for acne with isotretinoin

JH Yook, JY Han, JS Choi, HK Ahn, SW Lee… - Clinical …, 2012 - Taylor & Francis
Objective. We aimed to study the pregnancy outcomes of women exposed to isotretinoin and
to identify the factors influencing their decision to request an abortion. Methods. The study …

Isotretinoin: Still the cause of anxiety for teratogenicity

D Altıntaş Aykan, Y Ergün - Dermatologic Therapy, 2020 - Wiley Online Library
Isotretinoin is known as a potent teratogenic agent. Pregnancy should be ruled out before
isotretinoin is prescribed. In this study, we evaluated the fetal outcomes of pregnant women …

Can we ensure the safe use of known human teratogens? Introduction of generic isotretinoin in the US as an example

MA Honein, CA Moore, JD Erickson - Drug safety, 2004 - Springer
The prescription of known teratogenic medications requires a careful balance between
allowing women access to medications that they might need and avoiding unnecessary …

Isotretinoin exposure and pregnancy outcome: an observational study of the Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy

C Schaefer, R Meister… - Archives of gynecology and …, 2010 - Springer
Objective Apart from thalidomide, retinoids like isotretinoin are the strongest teratogens in
humans known today. The overall risk of birth defects is estimated as up to 30% after …

Fetal exposure to isotretinoin—an international problem

F Garcia-Bournissen, L Tsur, LH Goldstein… - Reproductive …, 2008 - Elsevier
BACKGROUND: Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at
minimizing isotretinoin exposure in pregnancy have been implemented in North America …

Bilateral Anotia In A Preterm Neonate After Maternal Retinoic Acid Exposure

C Zeybek, BS Karagol - Klinische Pädiatrie, 2023 - thieme-connect.com
Discussion Our patient did not have an anamnesis of consanguineous marriage or
gestational diabetes. There was consent that the infant's phenotype along with the maternal …