[HTML][HTML] Tamper-resistant drugs cannot solve the opioid crisis
There are many reasons why tamper-resistant formulations will not curb the opioid epidemic
overall. First, many such formulations simply include naloxone, which can counteract the …
overall. First, many such formulations simply include naloxone, which can counteract the …
Strategies to reduce the tampering and subsequent abuse of long-acting opioids: potential risks and benefits of formulations with physical or pharmacologic deterrents …
SP Stanos, P Bruckenthal, RL Barkin - Mayo Clinic Proceedings, 2012 - Elsevier
Increased prescribing of opioid analgesics for chronic noncancer pain may reflect
acceptance that opioid benefits outweigh risks of adverse events for a broadening array of …
acceptance that opioid benefits outweigh risks of adverse events for a broadening array of …
The implications of Tamper–Resistant formulations for Opioid rotation
M Pappagallo, M Sokolowska - Postgraduate Medicine, 2012 - Taylor & Francis
Because rates of both opioid prescribing and opioid abuse have increased, drug companies
have responded by considering strategies to make opioid formulations less attractive for …
have responded by considering strategies to make opioid formulations less attractive for …
Update on tamper-resistant drug formulations
MK Romach, KA Schoedel, EM Sellers - Drug and alcohol dependence, 2013 - Elsevier
An expert panel convened in 2005 by the College on Problems of Drug Dependence
(CPDD) to consider strategies to reduce the risk of prescription medication abuse concluded …
(CPDD) to consider strategies to reduce the risk of prescription medication abuse concluded …
Opioid extended-release tablets with improved tamper-resistant properties
JH Bartholomaeus, E Arkenau-Marić… - Expert opinion on drug …, 2012 - Taylor & Francis
Objective: To prepare a polyethylene oxide-based tablet with high mechanical strength that
would release an opioid for once-or twice-daily administration. This tablet would also create …
would release an opioid for once-or twice-daily administration. This tablet would also create …
[HTML][HTML] Approaches to improve pain relief while minimizing opioid abuse liability
LR Webster, PG Fine - The Journal of Pain, 2010 - Elsevier
Two strategies should greatly improve pain management while minimizing opioid abuse.
The first strategy involves the systematic implementation in every clinical practice of …
The first strategy involves the systematic implementation in every clinical practice of …
Validity testing of patient objections to acceptance of tamper-resistant opioid formulations
CE Argoff, SP Stanos, MS Wieman - Journal of Pain Research, 2013 - Taylor & Francis
Background Tamper-resistant formulations (TRFs) of oral opioid drugs are intended to
prevent certain types of abuse (eg, intranasal, intravenous). Patients raising objections to …
prevent certain types of abuse (eg, intranasal, intravenous). Patients raising objections to …
[HTML][HTML] Effective Canadian policy to reduce harms from prescription opioids: learning from past failures
CMAJ, December 6, 2016, 188 (17–18) 1241 to remove it from their drug formularies. 13
Oxycodone prescribing decreased, but there was a shift to prescribing other potent opioids …
Oxycodone prescribing decreased, but there was a shift to prescribing other potent opioids …
Changes in the dispensing of opioid medications in Canada following the introduction of a tamper-deterrent formulation of long-acting oxycodone: a time series …
T Gomes, A Mastorakos, JM Paterson… - … Open Access Journal, 2017 - cmajopen.ca
Background: In February 2012, a reformulated tamper-deterrent form of long-acting
oxycodone, OxyNeo, was introduced in Canada. We investigated the impact of the …
oxycodone, OxyNeo, was introduced in Canada. We investigated the impact of the …
Tamper-resistant opioid formulations in the treatment of acute pain
SD Passik - Advances in therapy, 2014 - Springer
Introduction Pain—including acute or persistent acute pain—is a common condition that is
increasingly being treated with opioids in the United States. The acute pain treatment setting …
increasingly being treated with opioids in the United States. The acute pain treatment setting …
