Rather than an iPLEDGE-type registry, Motherisk suggests a mandatory Web-based training
program and certification of physicians as a condition for prescribing isotretinoin. A similar …

We feel that the commentary by Gideon Koren and associates1 regarding safety concerns
related to isotretinoin has the potential to serve as a catalyst for safer use of this drug. We …

More than 25 years have passed since Peck et al. 1 described the dramatic effects of
isotretinoin in inducing prolonged remissions of severe acne. Within a year of its 1982 …

Topical isotretinoin (Retin-A) was introduced to the market in the early 1970s. In 1979, the
FDA approved the oral formulation of isotretinoin (Accutane) for the treatment of nodulocystic …

Information Services had the labelled indication. Moreover, although the drug was originally
intended to be prescribed by dermatologists, many family physicians now prescribe it. Of the …

Accutane (Roche Laboratories, Nutley, New Jersey), known by the generic name"
isotretinoin," is a prescription oral medication approved by the Food and Drug Administration …

The isotretinoin registry has arrived. It has a lofty goal of preventing all isotretinoin
pregnancies. How we got to this point and what the registry means to prescribers and …

Although birth defects are the most serious adverse effect of isotretinoin (AccutaneTM),
depression has also been reported. Recently, international and domestic reports of …

In a Canadian study published in CMAJ, the finding of 3.1 pregnancies per 1000 female
isotretinoin users between 1996–2011 is cause for concern for all prescribers of this …

pregnancies in females taking isotretinoin and to prevent pregnant females from taking
isotretinoin," iPLEDGE" monitors all prescriptions and dispensed doses of the medication." …