Background: Statins were initially used to improve cardiovascular outcomes in people with
established coronary artery disease, but recently their use has become more common in …

Background Statins have been shown to reduce the risk of all-cause mortality among
individuals with clinical history of coronary heart disease. However, it remains uncertain …

Background The extent to which individual statins vary in terms of clinical outcomes across
all populations, in addition to secondary and primary prevention has not been studied …

Background The beneficial effects of statins on cardiovascular mortality in secondary
prevention have been established in several long-term, placebo-controlled trials. However …

Importance A 2016 review for the US Preventive Services Task Force (USPSTF) found use
of statins for primary prevention of cardiovascular disease (CVD) was associated with …

Importance Cardiovascular disease (CVD), the leading cause of mortality and morbidity in
the United States, may be potentially preventable with statin therapy. Objective To …

Objective To synthesise evidence from exclusively primary prevention data on the
effectiveness of statins for prevention of cardiovascular disease (CVD), including stroke, and …

Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD)
risk. The use of these drugs for secondary prevention of CVD is well founded, but their …

Three-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly known as
statins, are widely available, inexpensive, and represent a potent therapy for treating …

ContextLowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of
recurrent coronary heart disease in middle-aged men. However, this effect has been …