tPA for acute stroke: balancing baseline imbalances

J Mann - CMAJ, 2002 - Can Med Assoc
1. Kappel J, Calissi P. Nephrology: 3. Safe drug prescribing for patients with renal
insufficiency. CMAJ 2002; 166 (4): 473-7. 2. Osborne R, Joel S, Grebenik K, Trew D, Slevin …

[HTML][HTML] Should Physicians Give Tpa to Patients with Acute Ischemic Stroke?: For: Thrombolytics in stroke: whose risk is it anyway?

DJ Robinson - Western Journal of Medicine, 2000 - ncbi.nlm.nih.gov
Stroke remains the leading cause of long-term disability in the United States. One third of
stroke patients presenting with severe disabilities cannot care for themselves. By 7 years …

The stroke-thrombolytic predictive instrument provides valid quantitative estimates of outcome probabilities and aids clinical decision-making

BM Demaerschalk - Stroke, 2006 - Am Heart Assoc
Computerized clinical decision support systems are increas-ingly popular in health sciences
and have been demonstrated to improve practitioner performance. 1 For an emergency …

Detriments of tPA for acute stroke in routine clinical practice.(Patient Oriented Evidence that Matters).

BL Novak, RW Force - Journal of Family Practice, 2003 - go.gale.com
* BACKGROUND What are the benefits and harms of tPA in routine clinical practice?
Thrombolytic agents have been used in acute stroke to limit the progression of ischemia …

Intravenous TPA for ischemic stroke patients: Houston experience 1996–2000

JC Grotta, AV Alexandrov, WS Burgin, M Long… - 2001 - Am Heart Assoc
40 Background: Implementation of intravenous (IV) tissue plasminogen activator (TPA)
therapy with the NINDS protocol has been reported with variable safety. Our center has an …

Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3-to 6-hour time window?

DM Kent, HP Selker, R Ruthazer, E Bluhmki, W Hacke - Stroke, 2006 - Am Heart Assoc
Background and Purpose—The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) uses
multivariate equations to predict outcomes with and without thrombolysis. We sought to …

[HTML][HTML] Thrombolysis in acute stroke–Authors' reply

J Emberson, KR Lees, P Lyden, C Baigent… - The Lancet, 2015 - thelancet.com
5 Lorenzano S, Ahmed N, Falcou A, et al. Does sex influence the response to intravenous
thrombolysis in ischemic stroke? Answers from safe implementation of treatments in Stroke …

Thrombolytic therapy for ischemic stroke: from clinical trials to clinical practice

JP Mohr - Jama, 2000 - jamanetwork.com
INTRAVENOUS TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA) for ischemic stroke has
broken a major therapeutic bar-rier, and much more progress is certain to follow. Steadily …

TPA use for stroke in the Registry of the Canadian Stroke Network

JO Nadeau, S Shi, J Fang, MK Kapral… - Canadian journal of …, 2005 - cambridge.org
Background: Thrombolytic therapy with recombinant tissue plasminogen activator (tPA) has
been shown to be cost-effective and safe. Thrombolysis for stroke with tPA is now a standard …

Thrombolytic therapy for acute ischemic stroke: a very great honor

PD Lyden - Stroke, 2019 - Am Heart Assoc
2598 Stroke September 2019 investigators at 3 stroke centers examined the safety and
clinical outcome following treatment with escalating doses of intravenous single-chain tPA …