What to do: Much of the data obtained on grapefruit juice–drug interactions involved
measuring serum drug concentrations in small numbers of healthy volunteers. Because of …

CME sequently, CYP3A4 activity in the small intestine is impaired until de novo synthesis
returns the enzyme to its previous level. This mechanism explains the important clinical …

A single glass of grapefruit juice can improve the oral bioavailability of a drug thus either
increasing its efficacy or enhancing its adverse effects particularly if the therapeutic index is …

Concomitant intake with grapefruit juice increases the concentrations of many drugs in
humans. The effect seems to be mediated mainly by suppression of the cytochrome P450 …

Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to
affect the metabolism of many medications, increasing the risk of toxicity and adverse effects …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …

Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur
via inhibition of CYP3A enzymes. As reported by Glaeser et al. 1 in the March 2007 issue of …

What is known and objective Grapefruit juice interacts with a number of drugs. This
commentary provides feedback on a previously proposed approach for predicting clinically …

Drug interactions with grapefruit: Whose responsibility is it to warn the public? Page 1 eP l-‘HERAPEUTICS
li VOLUME 61 NUMBER 4 APRIL 1997 COMMENTARY Drug interactions with grapefruit …

The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …