It is now known that several complications may arise from the prolonged use of heavy doses
of chloroquine. Keratopathy in the form of minute punctate yellow pigmentation may de¬ …

Several recent reports of irreversible retinal changes following chloroquine therapy have
suggested to some physicians that the drug may be too dangerous for clinical use. For this …

PERMANENT loss of vision from retinopathy may be a most serious sequel of prolonged
chloroquine therapy. This complication, recognized only after a decade of use of this drug, is …

Ocular complications of long-term chloroquine therapy were observed in 18 of 45 patients so
treated. This therapy was used in patients with rheumatoid arthritis, lupus erythematosus …

Seven patients with chloroquine retinopathy were examined ten years after their therapy
with chloroquine or hydroxychloroquine, or both, had been discontinued and an additional …

The literature has brought forward quite a number of retinopathy cases due to long term
chloroquine treatment, as reviewed eg by Voipio (1966). In Finland chloroquine has been …

DISCUSSION The cases described have many clear points of similarity. One of the
symptoms common to all three was an inability to fixate. Once this symptom had developed …

Introduction Chloroquine and its derivatives are being widely used today for the treatment of
such diseases as disseminated lupus erythematosus, discoid lupus, light sensitivity …

ANTIMALARIAL drugs are used in the treatment of lupus erythematosus and have been
used in the treatment of rheumatoid arthritis following the obser-vation by Page (1951) of the …

" On present evidence, the retinopathy here described results from treatment with
chloroquine compounds. As the corneal changes known to be produced by chloroquine …