Apolipoprotein E ε4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging
GYR Hsiung, AD Sadovnick, H Feldman - Cmaj, 2004 - Can Med Assoc
Background: Apolipoprotein E (ApoE) ε4 genotype is a well-established risk factor for
Alzheimer's disease (AD). However, its effect on predicting conversion from normal to …
Alzheimer's disease (AD). However, its effect on predicting conversion from normal to …
Apolipoprotein E ε4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis
T Kleiman, K Zdanys, B Black, T Rightmer… - Dementia and geriatric …, 2006 - karger.com
Abstract Objective: The apolipoprotein E (ApoE) Ε4 allele is a well-documented genetic risk
factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and …
factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and …
[HTML][HTML] The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study
A Gharbi-Meliani, A Dugravot, S Sabia, M Regy… - Alzheimer's research & …, 2021 - Springer
Background Approximately 25% of the general population carries at least one ε4 allele of
the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's …
the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's …
Plasma levels of apolipoprotein E and risk of dementia in the general population
KL Rasmussen, A Tybjærg‐Hansen… - Annals of …, 2015 - Wiley Online Library
Objective The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer
disease and dementia. However, it remains unclear whether plasma levels of apoE confer …
disease and dementia. However, it remains unclear whether plasma levels of apoE confer …
Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease
LW Bonham, EG Geier, CC Fan… - Annals of clinical …, 2016 - Wiley Online Library
Objective The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic
risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here …
risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here …
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease
N Mattsson, C Groot, WJ Jansen… - Alzheimer's & …, 2018 - Wiley Online Library
Abstract Introduction Apolipoprotein E (APOE) ε4 is the major genetic risk factor for
Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not …
Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not …
How can elderly apolipoprotein E ε4 carriers remain free from dementia?
Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia,
but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in …
but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in …
Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population
Background: Apolipoprotein E (APOE) polymorphisms are unequivocally associated with
risk for Alzheimer's disease (AD). It is crucial to understand how this genetic factor affects …
risk for Alzheimer's disease (AD). It is crucial to understand how this genetic factor affects …
Stroke and apolipoprotein E ε4 are independent risk factors for cognitive decline: a population-based study
MG Dik, DJH Deeg, LM Bouter, EH Corder, A Kok… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—Stroke and apolipoprotein E ε4 (ApoE ε4) are individually
important risk factors for cognitive decline, including Alzheimer disease. It has been …
important risk factors for cognitive decline, including Alzheimer disease. It has been …
Apolipoprotein E genotype and lifetime cognitive decline
NA Kozauer, MM Mielke, GKC Chan… - International …, 2008 - cambridge.org
Objective: The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline
was examined over 22 years in a large community-based population study. Method: The …
was examined over 22 years in a large community-based population study. Method: The …