Amyotrophic lateral sclerosis: is excitotoxicity the key?

G Krueger - CMAJ: Canadian Medical Association Journal, 1994 - ncbi.nlm.nih.gov
La cause de la sclerose laterale amyotrophique (SLA), maladie neuromusculaire
d6generative bien connue qui a tellement handicape Sue Rodriguez au cours des derniers …

Amyotrophic lateral sclerosis: human challenge for neuroscience.

LP Rowland - Proceedings of the National Academy of …, 1995 - National Acad Sciences
For an uncommon disease, amyotrophic lateral sclerosis (ALS) is the object of
disproportionate attention these days. Synonyms include Lou Gehrig's disease, Charcot …

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

JD Rothstein - Advances in neurology, 1995 - europepmc.org
A large number of studies have documented abnormalities of glutamate metabolism in ALS
patients or in postmortem ALS tissue. These abnormalities include altered synthetic …

Issues & Opinions: Amyotrophic lateral sclerosis: Lower motor neuron disease spreading to upper motor neurons

SM Chou, FH Norris - Muscle & Nerve: Official Journal of the …, 1993 - Wiley Online Library
Contrary to the recently reemphasized notion that the primary neuron involved in
amyotrophic lateral sclerosis (ALS) is the cortical (upper) motor neuron (UMN), we believe …

[CITATION][C] Amyotrophic lateral sclerosis: a critique of a hypothesis

G Karpati, J Kimura - Muscle & nerve, 1992 - Wiley Online Library
A medical hypothesis, to be potentially valuable, must be based on sound scientific
principles, consistent with most of the known facts pertaining to the topic, and testable with …

Controversies about amyotrophic lateral sclerosis.

LP Rowland - Neurologia (Barcelona, Spain), 1996 - europepmc.org
Controversy regarding amyotrophic lateral sclerosis (ALS) concerns aspects of relatively
little consequence (such as the role of lead intoxication or trauma in the pathogenesis of the …

[PDF][PDF] Amyotrophic Lateral Sclerosis

CureScience Institute - Disease Review, 2023 - diseasereview.scholasticahq.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
motor neurons. It is unclear what causes ALS, but recent research suggests that multiple …

Amyotrophic lateral sclerosis is a multifactorial disease

A Eisen - Muscle & Nerve: Official Journal of the American …, 1995 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is probably biphasic. An initial trigger (s) is followed by a
terminal cascade coinciding with the onset of neurological deficits. The terminal cascade …

[PDF][PDF] Pathogenese der amyotrophen Lateralsklerose

M Troger - ARCHIVES SUISSES DE NEUROLOGIE ET …, 2003 - pdfs.semanticscholar.org
Tröger M.[Pathogenesis of amyotrophic lateral sclerosis.] Schweiz Arch Neurol Psychiatr
2003; 154: 202–4. More than 100 years after the first account of amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis: current concepts

LL Amico, JP Antel - Postgraduate Medicine, 1981 - Taylor & Francis
Amyotrophie lateral sclerosis, a progressive disease characterized by selective loss of upper
and lower motor neurons, equals or exceeds multiple sclerosis in incidence. The clinical and …