A common perception that research is a costly diversion from clinical care exacerbates this
problem and makes it difficult to persuade sites to participate in clinical studies. Furthermore …

“How does the new knowledge that we generate change the way we practise medicine in
different health care settings?” asks Turnbull.“It is the practical application of knowledge to …

COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …

The Patient-Centered Outcomes Research Institute announces bold plans to build a
National Patient-Centered Clinical Research Network that will unite millions of patients …

• The COVID-19 global pandemic has highlighted both the fragility of patient engagement in
research and innovative developments in this sphere.• Better digital engagement of patient …

In this issue of JAMA, Janiaud et al1 present a meta-analysis of randomized clinical trials
(RCTs) of convalescent plasma for the treatment of patients with COVID-19. Based on an …

IT MAY APPEAR THAT THE CLINICAL RESEARCH ENTERPRISE is functioning well, even
thriving. Nearly 30 000 trials globally are recruiting patients, 1 and results from 75 trials are …

This is the introductory paper in a collection of four papers on the Strategy for Patient-
Oriented Research (SPOR) Evidence Alliance, a pan-Canadian research initiative that was …

Improving Clinical Trial Enrollment Despite formidable barriers to designing, implementing,
and completing clinical trials in the midst of a pandemic, there are ways to ensure that the …

Background The clinical research enterprise is not producing the evidence decision makers
arguably need in a timely and cost effective manner; research currently involves the use of …