Serotonin and dopamine neurotransmitter systems in the brain are generally thought to
function separately. In the presence of antidepressants that inhibit the reuptake of serotonin …

Considerable evidence has accrued in the last two decades to support the hypothesis that
alterations in serotonergic neuronal function in the central nervous system occur in patients …

Moncrieff et al.[1] report in a review of reviews that depression is not generally linked with
serotonin deficiency. This is hardly news to neuropharmacologists, which Moncrieff et al …

The monoamine hypothesis of depression posits that an imbalance in monoaminergic
neurotransmission is causally related to the clinical features of depression. Antidepressants …

Fifteen years have elapsed since we published this article focusing on the serotonin
transporter (SERT) 3. Although developed as a review, this report ultimately included …

The neurotransmitter serotonin is produced by neurons in the raphe nuclei of the brainstem,
which send axonal projections broadly to the cerebral cortex, the amygdala, and other brain …

Serotonin (5-HT) neurons constitute a tiny fraction of neurons in the brain (300 000 out of a
billion neurons in human brain [0.03%]), yet they send projections to virtually all regions of …

In their recently published systematic” umbrella” review, Moncrieff and colleagues conclude
that there is no consistent evidence that depression is caused by decreased serotonin …

This is a comment on" Commentary: The serotonin transporter in depression: Meta-analysis
of in vivo and post mortem findings and implications for understanding and treating …

Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), may alleviate
depressive symptoms but also leave residual symptoms. The mechanism of action of SSRIs …