176 JAMC• 18 JANV. 2005; 172 (2) induced hypothermia on chronic nicotine infusion. The
α4* mice were found to acquire a tolerance within 8 days at a dose of nicotine that produced …

Nicotine addiction is a worldwide epidemic that claims millions of lives each year. Genetic
deletion of α5 nicotinic acetylcholine receptor (nAChR) subunits has been associated with …

Rationale Nicotine addiction is characterized by two distinct behaviors, chronic compulsive
self-administration and the induction of a withdrawal syndrome upon cessation of nicotine …

This review article provides an overview of recent studies of nicotine dependence and
withdrawal that used genetically engineered mice. Major progress has been made in recent …

Although chronic nicotine produces dependence in mice, the role of specific nicotinic
receptors has not been examined in knockout animals. The present study utilized α7 …

Technological advances in testing have led to the discovery of genetic variants that
contribute to many illnesses including nicotine dependence. A multi-stage model of the …

Tobacco smoking is a leading preventable cause of death in the United States and produces
a major health and economic burden. Although the majority of smokers want to quit, few are …

Nicotinic receptors containing the α4 subunit (α4* nAChRs) have high sensitivity and are
widely expressed in the central nervous system, yet their contributions to behavioral …

Nicotinic acetylcholine receptors (nAChRs) are highly conserved between humans and non-
human primates. Conservation exists at the level of genomic structure, protein structure and …

The 15q25 gene cluster contains genes that code for the α5, α3, and β4 nicotinic
acetylcholine receptor (nAChRs) subunits, and in human genetic studies, has shown the …