Converging lines of evidence also suggest that antidepressants, particularly selective
serotonin reuptake inhibitors, can inhibit platelet aggregation by depleting platelet serotonin …

Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-
founded fear of bleeding. Drug and food interactions are frequently cited as causes of …

Ms TS is a 66-year-old woman who receives warfarin for prevention of systemic
embolization in the setting of hypertension, diabetes, and atrial fibrillation. She had a …

Physicians and pharmacists routinely advise patients receiving warfarin to take
acetaminophen for pain or fever because of its relative safety; however, a recent study …

Aims The objective of this paper is to systematically review the literature on drug–drug
interactions with warfarin, with a focus on patient‐important clinical outcomes. Methods …

Warfarin has been the mainstay of oral anticoagulant therapy for the past 60 years and it is
most commonly used to treat or prevent thrombosis or thromboembolism in patients with …

Management of warfarin drug interactions is often complicated by lack of information
regarding interactions with new drugs and with herbal medicinals. The pharmaceutical …

Warfarin is known to have extensive interactions with many classes of drugs. The literature
suggesting a relevant interaction between acetaminophen and warfarin is inconsistent …

Background. Bleeding is a serious adverse drug reaction associated with warfarin therapy,
often induced by interacting co-medication. Methods. We investigated the frequency and …

Observational studies in patients have shown a dose‐dependent enhancement of the
anticoagulant effect of warfarin by acetaminophen whereas pharmacodynamic studies in …