[HTML][HTML] A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
Context Prior mechanistic studies reported that omeprazole decreases the platelet inhibitory
effects of clopidogrel, yet the clinical significance of these findings is not clear. Objective To …
effects of clopidogrel, yet the clinical significance of these findings is not clear. Objective To …
[HTML][HTML] The drug–drug interaction between proton pump inhibitors and clopidogrel
WC Lau, PA Gurbel - Cmaj, 2009 - Can Med Assoc
• Alternative treatment strategies with drugs not dependent on cytochrome P450 2C19
should be considered for multidrug therapy in patients at high risk for recurrent myocardial …
should be considered for multidrug therapy in patients at high risk for recurrent myocardial …
Risk of adverse clinical outcomes with concomitant use of clopidogrel and proton pump inhibitors following percutaneous coronary intervention
E Gupta, D Bansal, J Sotos, K Olden - Digestive diseases and sciences, 2010 - Springer
Background Recent studies have suggested that proton pump inhibitors (PPIs) attenuate the
benefits of clopidogrel. The clinical relevance of this interaction in patients who have …
benefits of clopidogrel. The clinical relevance of this interaction in patients who have …
Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial
SP Dunn, TE Macaulay, DM Brennan, CL Campbell… - 2008 - Am Heart Assoc
Ex vivo data suggest that a pharmacokinetic interaction may exist between proton pump
inhibitors (PPIs) and clopidogrel, decreasing the antiplatelet effect of the latter. We assessed …
inhibitors (PPIs) and clopidogrel, decreasing the antiplatelet effect of the latter. We assessed …
Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study
M Charlot, O Ahlehoff, ML Norgaard… - Annals of internal …, 2010 - acpjournals.org
This article has been corrected. The original version (PDF) is appended to this article as a
supplement. Background: Controversy remains on whether the dual use of clopidogrel and …
supplement. Background: Controversy remains on whether the dual use of clopidogrel and …
No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis
CS Kwok, V Jeevanantham, B Dawn… - International journal of …, 2013 - Elsevier
Background Data from pharmacokinetic and pharmacodynamic studies indicate that the
adverse clopidogrel–proton pump inhibitor (PPI) interaction may vary between PPIs, with …
adverse clopidogrel–proton pump inhibitor (PPI) interaction may vary between PPIs, with …
Meta‐analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel
CS Kwok, YK Loke - Alimentary pharmacology & therapeutics, 2010 - Wiley Online Library
Background Recent studies have suggested an adverse interaction between proton pump
inhibitors (PPI) and clopidogrel. Aim To perform a meta‐analysis of cardiovascular outcomes …
inhibitors (PPI) and clopidogrel. Aim To perform a meta‐analysis of cardiovascular outcomes …
Drug–drug interaction between clopidogrel and the proton pump inhibitors
NB Norgard, KD Mathews… - Annals of …, 2009 - journals.sagepub.com
Objective: To evaluate the interaction between clopidogrel and proton pump inhibitors
(PPIs). Data Sources: Literature retrieval was accessed through PubMed (1980–January …
(PPIs). Data Sources: Literature retrieval was accessed through PubMed (1980–January …
Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs
IJ Douglas, SJW Evans, AD Hingorani, AM Grosso… - Bmj, 2012 - bmj.com
Objective To measure the association between use of proton pump inhibitors and a range of
harmful outcomes in patients using clopidogrel and aspirin. Design Observational cohort …
harmful outcomes in patients using clopidogrel and aspirin. Design Observational cohort …