[HTML][HTML] Should people with asymptomatic carotid artery stenosis undergo endarterectomy for primary stroke prevention?

DJ Gladstone, DJ Sahlas - CMAJ, 2004 - Can Med Assoc
Background: Carotid endarterectomy (CE) is well established as a beneficial procedure for
reducing the risk of stroke among patients with symptomatic high-grade carotid artery …

Endarterectomy, best medical treatment or both for stroke prevention in patients with asymptomatic carotid artery stenosis

P Cardona, F Rubio, S Martinez-Yélamos… - Cerebrovascular …, 2007 - karger.com
Carotid endarterectomy (CEA) is currently frequently performed in subjects with
asymptomatic carotid artery stenosis over 70%, as clinical trials like the Asymptomatic …

[HTML][HTML] 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

A Halliday, M Harrison, E Hayter, X Kong, A Mansfield… - The Lancet, 2010 - thelancet.com
Background If carotid artery narrowing remains asymptomatic (ie, has caused no recent
stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces …

Vascular viewpoint

N Mohammed, SS Anand - Vascular medicine, 2005 - journals.sagepub.com
Question: Is carotid endarterectomy (CEA) an effective and safe treatment for the prevention
of stroke among patients with> 60% internal carotid artery stenosis who had no neurologic …

Ten-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

A Halliday, M Harrison, E Hayter - Journal of Vascular Surgery, 2011 - jvascsurg.org
Conclusion: Successful carotid endarterectomy (CEA) in asymptomatic patients aged< 75
years reduces 10-year risk of stroke. Half of the risk reduction is in the reduction of disabling …

Medical treatment of carotid endarterectomy patients requires attention

T Sairanen1, P Vikatmaa2, JM Lindholm1… - Neurological …, 2012 - Taylor & Francis
Objectives: The benefits of prophylactic carotid endarterectomy (CEA) together with best
medical treatment (BMT) are well-established. Early initiation of proper medical treatment …

Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial

MRC Asymptomatic Carotid Surgery Trial (ACST) … - The Lancet, 2004 - Elsevier
BACKGROUND: Among patients with substantial carotid artery narrowing but no recent
neurological symptom (stroke or transient ischaemia), the balance of surgical risks and …

Multicenter review of preoperative risk factors for endarterectomy for asymptomatic carotid artery stenosis

LB Goldstein, GP Samsa, DB Matchar, EZ Oddone - Stroke, 1998 - Am Heart Assoc
Background and Purpose—The benefit of carotid endarterectomy is highly dependent on
surgical risk. However, little data are available concerning factors affecting the risk of …

Carotid artery surgery to reduce long-term stroke rates: individual patient data meta-analysis of the randomised trials in asymptomatic patients

A Halliday, R Peto, R Bulbulia, D Morris… - Available at SSRN …, 2021 - papers.ssrn.com
Background: Among patients with severe carotid artery stenosis but no recent symptoms
from it, carotid surgery involves hazards, but then reduces long-term stroke rates. Triple-drug …

Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomized controlled trial. MRC …

N Mohammed, SS Anand - Vascular Medicine (London, England), 2005 - europepmc.org
Results Among patients randomized to immediate CEA (50% had CEA by 1 month, 88% by
1 year) versus deferred, the incidence of stroke or death at 5 years was 6.4% versus …