Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy

D Henry, C Dormuth, B Winquist, G Carney, S Bugden… - Cmaj, 2016 - Can Med Assoc
Background: Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks
of pregnancy during isotretinoin therapy are well recognized, there are doubts about the …

[HTML][HTML] A pregnancy-prevention program in women of childbearing age receiving isotretinoin

AA Mitchell, CM Van Bennekom… - New England Journal of …, 1995 - Mass Medical Soc
Background Isotretinoin is effective in treating severe acne, but it is also teratogenic. To
minimize pregnancies among exposed women, the manufacturer, together with the US Food …

Isotretinoin use and compliance with the Dutch Pregnancy Prevention Programme: a retrospective cohort study in females of reproductive age using pharmacy …

M Teichert, LE Visser, M Dufour, E Rodenburg… - Drug safety, 2010 - Springer
Background: Isotretinoin is very effective in the treatment of severe acne. However, because
of the teratogenic properties of this agent an isotretinoin Pregnancy Prevention Programme …

Pregnancy outcomes and factors associated with voluntary pregnancy termination in women who had been treated for acne with isotretinoin

JH Yook, JY Han, JS Choi, HK Ahn, SW Lee… - Clinical …, 2012 - Taylor & Francis
Objective. We aimed to study the pregnancy outcomes of women exposed to isotretinoin and
to identify the factors influencing their decision to request an abortion. Methods. The study …

A comparative review of the isotretinoin pregnancy risk management programs across four continents

T Kovitwanichkanont, T Driscoll - International Journal of …, 2018 - Wiley Online Library
Isotretinoin has revolutionized the treatment of severe acne vulgaris, a condition which if left
untreated may result in significant socio‐psychological implications for those affected …

Isotretinoin, pregnancies, abortions and birth defects: a population‐based perspective

A Bérard, L Azoulay, G Koren, L Blais… - British journal of …, 2007 - Wiley Online Library
What is already known about this subject• As of now, no population‐based data exist on the
incidence of pregnancy, elective abortions, and birth defects while on isotretinoin.• From …

Use of the retinoid pregnancy prevention program in Canada: patterns of contraception use in women treated with isotretinoin and etretinate

A Pastuszak, G Koren, MJ Rieder - Reproductive Toxicology, 1994 - Elsevier
We sought to describe demographic characteristics of and pattern of contraception use by
Canadian women prescribed synthetic retinoids who voluntarily contacted the Motherisk …

Concomitant use of isotretinoin and contraceptives before and after iPledge in the United States

SP Pinheiro, EM Kang, CY Kim… - … and drug safety, 2013 - Wiley Online Library
Purpose The major concern associated with isotretinoin treatment is its high teratogenic
potential. Therefore, ensuring use of contraception while on therapy is an important strategy …

Epidemiology of isotretinoin exposure during pregnancy

WS Dai, JM LaBraico, RS Stern - Journal of the American Academy of …, 1992 - Elsevier
Background: Exposure to isotretinoin during pregnancy is associated with a high risk of
major fetal malformations. Objective: Our purpose was to determine the reasons for and …

Fetal exposure to isotretinoin—an international problem

F Garcia-Bournissen, L Tsur, LH Goldstein… - Reproductive …, 2008 - Elsevier
BACKGROUND: Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at
minimizing isotretinoin exposure in pregnancy have been implemented in North America …