Amyloid B protein and Alzheimer disease

D Square - CMAJ, 1997 - Can Med Assoc
Amyloid beta protein is predominant in senile plaques, the neuropathologic hallmarks of
Alzheimer disease. Researchers in Winnipeg have shown that this protein can overstimulate …

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

CL Masters, DJ Selkoe - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …

The Amyloid Hypothesis and the clearance and degradation of Alzheimer's β-peptide

H LeVine III - Journal of Alzheimer's Disease, 2004 - content.iospress.com
The second generation of therapeutic strategies for Alzheimer's disease (AD) embraces the
Amyloid Hypothesis, which asserts that through a series of events not completely …

Amyloid inhibitors and Alzheimer's disease.

W Xia - Current opinion in investigational drugs (London …, 2003 - europepmc.org
Neuritic plaques composed of amyloid beta-protein (A beta) are an early and invariant
neuropathological feature of Alzheimer's disease (AD). The current preclinical search for …

New drug offers hope for better Alzheimer's treatment

C Bateman - CME: Your SA Journal of CPD, 2012 - go.gale.com
A new class of drug shows promise of in future offering a new form of treatment for
Alzheimer's disease, as well as helping fight multiple sclerosis and traumatic brain injury …

[PDF][PDF] Alzheimer's disease and the amyloid β protein: what is the role of amyloid?

DH Small, CA McLean - Journal of neurochemistry, 1999 - academia.edu
Alzheimer's disease (AD) is characterized by the deposition of amyloid in the extracellular
compartment of the brain in the form of congophilic amyloid angiopathy (CAA) and amyloid …

Role of the β-amyloid precursor protein in Alzheimer's disease

F Ashall, AM Goate - Trends in biochemical sciences, 1994 - cell.com
ALZHEIMER'S DISEASE (AD) was first described in a 51-year-old patient in 1907 by the
Bavarian psychiatrist, Alois AlzheimerL The disease begins with loss of short-term memory; …

Alzheimer's disease and the amyloid-β peptide

MP Murphy, H LeVine III - Journal of Alzheimer's disease, 2010 - content.iospress.com
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …

Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease

C Soto - Molecular medicine today, 1999 - cell.com
Alzheimer's disease is a devastating degenerative disorder of the brain for which there is no
cure or effective treatment. Although the etiology of Alzheimer's disease is not fully …

Advances in the Treatment of Alzheimer's Disease

MS Rafii - Molecular and Cellular Therapeutics, 2012 - Wiley Online Library
An estimated 5.3 million Americans of all ages have Alzheimer's disease. This figure
includes 5.1 million people aged 65 and older and 200 000 individuals under the age of 65 …