Discussion The association between chronic gastrointestinal bleeding due to
angiodysplasia and calcific aortic stenosis was first described in 1958 by Edward Heyde and …

Edward Heyde, an internist, remarked in correspondence to the New England Journal of
Medicine in 1958 that he had seen “at least 10 patients with calcific aortic stenosis who had …

Heyde syndrome is characterized by an association between gastrointestinal (GI) bleeding
and calcific aortic stenosis (AS). Although the course of disease progression that links AS …

Heyde syndrome is a triad of aortic stenosis, an acquired coagulopathy and anaemia due to
bleeding from intestinal angiodysplasia. The evidence that aortic stenosis is the root cause …

In 1958 EC Heyde reported on the association of aortic valve stenosis and gastrointestinal
bleeding, and defined a syndrome carrying his name today [1]. In 1992, Warkentin et al …

Obscure gastrointestinal (GI) bleeding can be a perplexing and difficult problem in elderly
patients, especially if they are hemodynamically unstable. If aortic stenosis is also present …

Aortic valve stenosis can be complicated by gastrointestinal bleeding from angiodysplasia. A
deficiency of high molecular weight multimers of von Willebrand factor (vWF)(type 2A von …

Aortic valve stenosis is known to be associated with loss of high molecular von Willebrand
multimers. This can lead to gastrointestinal bleeding in patients with gastrointestinal …

Aortic valve stenosis can be complicated by recurrent gastrointestinal bleeding, particularly
that due to angiodysplasia, also called Heyde syndrome. Recently, acquired type 2A von …

1Third Department of Internal Medicine, Nara Medical University, Nara, Japan 2Department
of Endoscopy, Nara Medical University, Nara, Japan Heyde syndrome describes the triad of …