The use of D-penicillamine in the treatment of rheumatoid arthritis has led to the recognition
of a variety of adverse effects, such as proteinuna, nephrotic syndrome, thrombocytopenia …

D-penicillamine is not generally considered to cause hepatic damage. Cholestatic jaundice
developed in a patient with rheumatoid arthritis 4 weeks after penicillamine was added to his …

Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving
D-penicillamine. Both recovered after withdrawal of the drug. These cases and a review of …

DISCUSSION At least eight previous case reports have implicated D-penicillamine as a
cause of hypersensitivity-induced cholestatic jaundice (5-1 1). Clinical and laboratory data of …

Excerpt D-penicillamine is used for the treatment of active rheumatoid arthritis, Wilson's
Disease, and cystinuria. It has been reported to be implicated as a cause of autoimmune …

Acute hypersensitivity pneumonitis is not a known side effect of D-penicillamine. Also, there
are only a few reports of cholestatic hepatitis caused by this drug. The present report …

To assess toxicity of D-penicillamine a retrospective chart review was performed on 63
patients with rheumatoid arthritis receiving penicillamine. These patients had a total of 83 …

Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment
with D-penicillamine are reviewed and a fourteenth case is described. Twelve of the …

Myasthenia may occur as a rare side effect of D penicillamine therapy (1, 2). The data we
wish to report have been collected from throughout the world since no more than one case …

Dermatomyositis complicating penicillamine Page 1 Annals of the Rheumatic Diseases, 1977,
36, 94-95 Case report Dermatomyositis complicating penicillamine treatment L. FERNANDES …