[HTML][HTML] Managing drug shortages during a pandemic: tocilizumab and COVID-19
• Drug shortages during a pandemic can result from sudden increases in demand and
disruptions in supply chains.• Health systems can rapidly respond to shortages of essential …
disruptions in supply chains.• Health systems can rapidly respond to shortages of essential …
[HTML][HTML] Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort study
S Stukas, G Goshua, A Kinkade, R Grey… - The Lancet Regional …, 2022 - thelancet.com
Background Interleukin-6 inhibitors reduce mortality in severe COVID-19. British Columbia
began using tocilizumab 8 mg/kg (maximum 800 mg) in January 2021 in critically ill patients …
began using tocilizumab 8 mg/kg (maximum 800 mg) in January 2021 in critically ill patients …
Rationalizing the Use of COVID-19 Questionable Efficacy Drugs in a Low Middle-income Country: A Hospital Tocilizumab Committee Experience.
N Hegde, A Kumar, GK Batra, M Devnani… - The Journal of the …, 2023 - europepmc.org
Background Only corticosteroids have confirmed mortality benefits in coronavirus disease of
2019 (COVID-19). Rational use of costlier drugs with questionable benefits poses a great …
2019 (COVID-19). Rational use of costlier drugs with questionable benefits poses a great …
[HTML][HTML] Pharmacokinetic/pharmacodynamic considerations of alternate dosing strategies of tocilizumab in COVID-19
E Leung, RL Crass, SCJ Jorgensen… - Clinical …, 2022 - Springer
Tocilizumab is one of few treatments that have been shown to improve mortality in patients
with coronavirus disease 2019 (COVID-19), but increased demand has led to relative global …
with coronavirus disease 2019 (COVID-19), but increased demand has led to relative global …
Tocilizumab for hospitalized patients with COVID-19
K Afra, LYC Chen, D Sweet - CMAJ, 2021 - Can Med Assoc
1. Chen LYC, Hoiland RL, Stukas S, et al. Confronting the controversy: interleukin-6 and the
COVID-19 cytokine storm syndrome. Eur Respir J 2020; 56: 2003006. 2. Product …
COVID-19 cytokine storm syndrome. Eur Respir J 2020; 56: 2003006. 2. Product …
Off-label real world experience using tocilizumab for patients hospitalized with COVID-19 disease in a regional community health system: a case-control study
M Ramaswamy, P Mannam, R Comer, E Sinclair… - medrxiv, 2020 - medrxiv.org
Abstract Objective To determine if Tocilizumab treatment in patients hospitalized with
laboratory confirmed SARS-CoV-2 infection and subsequent COVID-19 disease provides …
laboratory confirmed SARS-CoV-2 infection and subsequent COVID-19 disease provides …
Covid-19 controversies: the tocilizumab chapter
EK McCreary, NJ Meyer - Bmj, 2021 - bmj.com
More than two million people have so far died from coronavirus disease 2019 (covid-19)
globally. With hospitals and intensive care units at or exceeding capacity in much of the …
globally. With hospitals and intensive care units at or exceeding capacity in much of the …
[HTML][HTML] Towards fixed dosing of tocilizumab in ICU-admitted COVID-19 patients: results of an observational population pharmacokinetic and descriptive …
DJAR Moes, DJ van Westerloo, SM Arend… - Clinical …, 2022 - Springer
Abstract Background and Objective In the randomized controlled trial REMAP-CAP, it was
shown that next to dexamethasone, the interleukin (IL)-6 receptor antagonist tocilizumab …
shown that next to dexamethasone, the interleukin (IL)-6 receptor antagonist tocilizumab …
[HTML][HTML] The impact of COVID-19 on essential medicines and personal protective equipment availability and prices in Saudi Arabia
This was a questionnaire-based cross-sectional study that explored the impact of the COVID-
19 pandemic on the availability of essential medicine and personal protective equipment …
19 pandemic on the availability of essential medicine and personal protective equipment …
Tackling medicine shortages during and after the COVID-19 pandemic: Compilation of governmental policy measures and developments in 38 countries
S Vogler - Health Policy, 2024 - Elsevier
In response to increasing shortages of medicines, governments have implemented
legislative and non-legislative policy measures. This study aimed to map these policies …
legislative and non-legislative policy measures. This study aimed to map these policies …