1. Al-Omran M, Mamdani MM, McLeod R. Epidemiologic features of acute appendicitis in
Ontario, Canada. Can J Surg 2003; 46: 263-8. 2. CODA Collaborative; Flum DR, Davidson …

2. Telem DA. Shared decision making in uncomplicated appendicitis: it is time to include
nonoperative management. JAMA. 2016; 315: 811–812. 3. Hasday SJ, Chhabra KR, Dimick …

Importance Antibiotic therapy for acute uncomplicated appendicitis is effective in adult
patients, but its application in pediatric patients remains controversial. Objective To compare …

Objective: The aim of this meta-analysis was to summarize the current available evidence on
nonoperative management (NOM) with antibiotics for uncomplicated appendicitis, both in …

Background This aim of this study was to provide an updated meta-analysis comparing
antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated …

EBM PEARL: THE META-ANALYSIS I2 STATISTIC: A primary meta-analysis validity issue is
combining studies that are measuring the same outcome in the same way. At times …

In 2015, the initial APPAC trial that compared surgery (n= 273 [272 included in the primary
analysis]) vs antibiotics alone (n= 257 [256 included in primary analysis]) in the treatment of …

Background Acute appendicitis is one of the most common etiologies of an acute abdomen
in the emergency department and first-line standard surgical care for the condition has …

OBJECTIVE: The aim of the study was to review evidence-based data regarding the use of
antibiotics for the treatment of appendicitis in children. DATA SOURCE: Data were obtained …

METHODS PubMed (Medline) and EMBASE were searched using defined search terms in
June 2015 to identify RCTs that compared antibiotics with appendectomy for acute …