Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial

A Haidar, L Legault, M Dallaire, A Alkhateeb, A Coriati… - Cmaj, 2013 - Can Med Assoc
Background: Most patients with type 1 diabetes do not achieve their glycemic targets. We
aimed to assess the efficacy of glucose-responsive insulin and glucagon closed-loop …

Glucose-responsive insulin delivery for type 1 diabetes: The artificial pancreas story

L Bally, H Thabit, R Hovorka - International journal of pharmaceutics, 2018 - Elsevier
Insulin replacement therapy is integral to the management of type 1 diabetes, which is
characterised by absolute insulin deficiency. Optimal glycaemic control, as assessed by …

Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type …

A Haidar, L Legault, V Messier, TM Mitre… - The lancet Diabetes & …, 2015 - thelancet.com
Background The artificial pancreas is an emerging technology for the treatment of type 1
diabetes and two configurations have been proposed: single-hormone (insulin alone) and …

Single-and dual-hormone artificial pancreas for overnight glucose control in type 1 diabetes

A Haidar, R Rabasa-Lhoret, L Legault… - The Journal of …, 2016 - academic.oup.com
Context: The added benefit of glucagon in artificial pancreas systems for overnight glucose
control in type 1 diabetes has not been fully explored. Objective: The objective of the study …

Closed loop insulin delivery in diabetes

T Battelino, JŠ Omladič, M Phillip - Best Practice & Research Clinical …, 2015 - Elsevier
The primary goal of type 1 diabetes treatment is attaining near-normal glucose values. This
currently remains out of reach for most people with type 1 diabetes despite intensified insulin …

The artificial pancreas and type 1 diabetes

M Nwokolo, R Hovorka - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Diabetes technologies represent a paradigm shift in type 1 diabetes care. Continuous
subcutaneous insulin infusion (CSII) pumps and continuous glucose monitors (CGM) …

Feasibility of closed-loop insulin delivery in type 2 diabetes: a randomized controlled study

K Kumareswaran, H Thabit, L Leelarathna… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Closed-loop insulin delivery offers a promising treatment option, but to date, it
has only been evaluated in type 1 diabetes. Our aim was to evaluate the feasibility of fully …

[HTML][HTML] Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 …

L Bally, H Thabit, H Kojzar, JK Mader… - The Lancet Diabetes & …, 2017 - thelancet.com
Background Tight control of blood glucose concentration in people with type 1 diabetes
predisposes to hypoglycaemia. We aimed to investigate whether day-and-night hybrid …

Dual‐hormone artificial pancreas for glucose control in type 1 diabetes: A meta‐analysis

B Zeng, H Jia, L Gao, Q Yang, K Yu… - Diabetes, Obesity and …, 2022 - Wiley Online Library
Aim To evaluate the efficacy and safety of a dual‐hormone artificial pancreas (DH) in type 1
diabetes. Material and Methods PubMed, Embase, the Cochrane Library and ClinicalTrials …

Fully closed loop glucose control with a bihormonal artificial pancreas in adults with type 1 diabetes: an outpatient, randomized, crossover trial

H Blauw, AJ Onvlee, M Klaassen, AC Van Bon… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To demonstrate the performance and safety of a bihormonal (insulin and
glucagon) artificial pancreas (AP) in adults with type 1 diabetes. RESEARCH DESIGN AND …