Many antibiotics are eliminated renally and dosage adjustments are commonly made in
patients with renal insufficiency. This is a critical review of antibiotic pharmacokinetics in …

Peritoneal dialysis has become an accepted treatment modality for end-stage renal disease.
The introduction of continuous ambulatory peritoneal dialysis (CAPD) has further …

Five tables are presented that provide guidelines for drug usage in patients with renal
insufficiency. The data are derived from the current medical literature. If specific information …

The pharmacokinetics of mezlocillin were examined in 8 patients with normal renal function
(inulin clearance,> 80 ml/min per 1.73 m2), 32 patients with moderately reduced renal …

Excerpt Gram-negative bacterial infections frequently complicate the management of
patients undergoing peritoneal dialysis for renal failure. All require immediate and vigorous …

The isolation of the penicillin nucleus, 6-amino-penicillanic acid, 7 and its exploitation to
modify the penicillin molecule by the addition of a variety of side chains has made feasible …

Four tables describe maintenance dosage intervals for common therapeutic agents used in
patients with renal disease. Particular emphasis has been given to the use of biological half …

With the current high prevalence of infection caused by methicillin-resistant Staphylococcus
aureus (MRSA) strains but in light of the general belief that β-lactam antibiotics are more …

Antibiotics continue to be used frequently to treat CAPD-associated peritonitis. Selection of
appropriate antibiotic doses and routes of administration has been based largely upon …

Renal failure impairs urinary excretion of drugs and may also modify drug action by
alterations in protein binding, distribution, biotransformation and, possibly, by retention of …