Autophagy contributes to metabolic reprogramming and therapeutic resistance in pancreatic tumors

G Reyes-Castellanos, N Abdel Hadi, A Carrier - Cells, 2022 - mdpi.com
Metabolic reprogramming is a feature of cancers for which recent research has been
particularly active, providing numerous insights into the mechanisms involved. It occurs …

Pancreatic cancer, radiomics and artificial intelligence

L Marti-Bonmati, L Cerdá-Alberich… - The British Journal of …, 2022 - academic.oup.com
Patients with pancreatic ductal adenocarcinoma (PDAC) are generally classified into four
categories based on contrast-enhanced CT at diagnosis: resectable, borderline resectable …

Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression

V Gouirand, T Gicquel, EC Lien, E Jaune‐Pons… - The EMBO …, 2022 - embopress.org
Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients
and therefore must adapt their metabolism to ensure proliferation. In some physiological …

Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis

NH Stoecklein, G Fluegen, R Guglielmi, RPL Neves… - Molecular Cancer, 2023 - Springer
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic
adenocarcinoma (PDAC) stems from their extremely low concentration in the whole …

hENT1 as a Predictive Biomarker in PDAC—Response

S Perera, GH Jang, R Grant, F Notta, B Grunwald… - Clinical Cancer …, 2023 - AACR
We would like to thank Boyd and colleagues for their thoughtful comments on our work
demonstrating hENT1 as a predictive biomarker for gemcitabine and nab-paclitaxel (GnP) in …

[HTML][HTML] Evaluation of the cytotoxic and immunomodulatory effects of sonodynamic therapy in human pancreatic cancer spheroids

F Foglietta, P Panzanelli, R Pizzo, M Giacone… - … of Photochemistry and …, 2024 - Elsevier
Sonodynamic therapy (SDT) exploits the energy generated by ultrasound (US) to activate
sound-sensitive drugs (sonosensitizers), leading to the generation of reactive oxygen …

[HTML][HTML] Determinants of gemcitabine response in pancreatic cancer: are we there?

OM Fitzpatrick, GM O'Kane - Journal of Gastrointestinal Oncology, 2023 - ncbi.nlm.nih.gov
1Department of Medical Oncology, Trinity St. James's Cancer Institute, Dublin, Ireland;
2Princess Margaret Cancer Centre, Toronto, Canada Correspondence to: Grainne M …

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional …

N Landon-Brace, BT Innes, S Latour, JL Cadavid, IL Co… - bioRxiv, 2024 - biorxiv.org
Pancreatic ductal adenocarcinoma (PDAC) is a high-mortality cancer characterized by its
aggressive, treatment-resistant phenotype and a complex tumour microenvironment (TME) …

Impact of Sarcopenia on Patients with Localized Pancreatic Ductal Adenocarcinoma Receiving FOLFIRINOX or Gemcitabine as Adjuvant Chemotherapy

V Mortier, F Wei, A Pellat, U Marchese, A Dohan… - Cancers, 2022 - mdpi.com
Simple Summary Pancreas cancer will become the second deadliest cancer in 2030. One-
third of patients with pancreatic cancer are treated with surgery followed by intravenous …

Inverted Y‐shaped technique for complex superior mesenteric/portal vein reconstruction in pancreatoduodenectomy for locally advanced pancreatic head ductal …

B Kaluba, N Kuriyama, T Ito… - Annals of …, 2023 - Wiley Online Library
Most pancreatoduodenectomy (PD) procedures for locally advanced pancreatic head
adenocarcinoma (PDAC) require superior mesenteric/portal vein (SMV/PV) axis resection …