[HTML][HTML] Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …
Non-viral vector-mediated gene therapy for ALS: Challenges and future perspectives
GR Ediriweera, L Chen, JJ Yerbury… - Molecular …, 2021 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, for which
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …
[HTML][HTML] Approaches to gene modulation therapy for ALS
KE Meijboom, RH Brown - Neurotherapeutics, 2022 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease for which there is
currently no robust therapy. Recent progress in understanding ALS disease mechanisms …
currently no robust therapy. Recent progress in understanding ALS disease mechanisms …
[HTML][HTML] Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces
R Pugliese, R Sala, S Regondi, B Beltrami… - Journal of Neurology, 2022 - Springer
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
[HTML][HTML] The role and therapeutic potential of the integrated stress response in amyotrophic lateral sclerosis
E Marlin, C Viu-Idocin, M Arrasate… - International journal of …, 2022 - mdpi.com
In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical
and spinal cord motor neurons triggers the activation of the integrated stress response (ISR) …
and spinal cord motor neurons triggers the activation of the integrated stress response (ISR) …
[HTML][HTML] HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex
M Dell'Orco, V Sardone, AS Gardiner… - Neurobiology of …, 2021 - Elsevier
The neuronal RNA-binding protein (RBP) HuD plays an important role in brain development,
synaptic plasticity and neurodegenerative diseases such as Parkinson's (PD) and …
synaptic plasticity and neurodegenerative diseases such as Parkinson's (PD) and …
[HTML][HTML] The multifaceted role of GPCRs in amyotrophic lateral sclerosis: a new therapeutic perspective?
Amyotrophic lateral sclerosis (ALS) is a degenerating disease involving the motor neurons,
which causes a progressive loss of movement ability, usually leading to death within 2 to 5 …
which causes a progressive loss of movement ability, usually leading to death within 2 to 5 …
[HTML][HTML] ROS: Executioner of regulating cell death in spinal cord injury
Z Yin, B Wan, G Gong, J Yin - Frontiers in Immunology, 2024 - frontiersin.org
The damage to the central nervous system and dysfunction of the body caused by spinal
cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by …
cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by …
[HTML][HTML] Molecular dynamics and protein frustration analysis of human fused in Sarcoma protein variants in Amyotrophic Lateral Sclerosis type 6: An In Silico …
Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disorder.
The disease is characterized by degeneration of upper and lower motor neurons, leading to …
The disease is characterized by degeneration of upper and lower motor neurons, leading to …
A qualitative meta-synthesis of evidence (meta-ethnography) exploring the personal experiences of gastrostomy tube in neurodegenerative diseases: a case of motor …
Purpose The lived experiences of a gastrostomy tube (GT) in adults with neurodegenerative
diseases (NDDs) are not well understood. The aim of this qualitative meta-synthesis was to …
diseases (NDDs) are not well understood. The aim of this qualitative meta-synthesis was to …