With the ageing population globally, tuberculosis (TB) in older people becomes a major
clinical and public health challenge. In many Asian countries, especially those located in the …

Background Control of latent tuberculosis infection (LTBI) is an important step towards
tuberculosis elimination. Preventive treatment will prevent the development of disease in …

Often the literature makes assertions of medical product effects on the basis of 'p< 0.05'. The
underlying premise is that at this threshold, there is only a 5% probability that the observed …

Background An important problem limiting treatment of latent tuberculosis infection is the
occurrence of adverse events with isoniazid. We combined populations from phase 2 and …

Ensuring adherence and support during treatment of tuberculosis (TB) is a major public
health challenge. Digital health technologies could help improve treatment outcomes. We …

Latent tuberculosis infection (LTBI) management is now a critical component of the World
Health Organization's End TB Strategy. In this randomised controlled trial (Chinese Clinical …

Background In the last 20 years, China ramped up a DOTS (directly observed treatment,
short-course)-based tuberculosis (TB) control program with 80% population coverage …

Background Elderly persons have the highest rates of tuberculosis (TB) in the United States
compared to all other age groups. A systematic literature review was conducted to determine …

BACKGROUND: We assessed treatment uptake and completion for 6 months of isoniazid
(6H) and 3 months of isoniazid plus rifapentine weekly (3HP) in a programmatic setting in …

Background: Diabetes mellitus (DM) confers a higher risk for tuberculosis (TB). Yet, TB
screening and chemoprophylaxis for latent TB infection (LTBI) in DM remains controversial …