The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

The use of extracorporeal membrane oxygenation (ECMO) support for cardiac and
respiratory failure has increased in recent years. Improvements in ECMO oxygenator and …

Background Recombinant factor VIIa (rFVIIa) is licensed for use in patients with haemophilia
and inhibitory allo‐antibodies. It is also increasingly being used for off‐license indications to …

Massive haemorrhage requires massive transfusion (MT) to maintain adequate circulation
and haemostasis. For optimal management of massively bleeding patients, regardless of …

Background: Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia,
is increasingly used for off-label indications. Purpose: To evaluate the benefits and harms of …

Acidosis, hypothermia and hypocalcaemia are determinants for morbidity and mortality
during massive hemorrhages. However, precise pathological mechanisms of these …

Objective The purpose of this review is to present the progressive extension of the concept
of damage control resuscitation, focusing on the prehospital phase. Article type Review of …

ABSTRACT Purpose/Aim: Animal models of traumatic brain injury (TBI) provide powerful
tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used …

In women with postpartum hemorrhage, the need to transfuse a large amount of blood
products is frequent. The ABCD of massive transfusions—Assessment/Activation, Blood …

Trauma is a leading cause of death and disability. Hemorrhage is the major mechanism
responsible for death during the first 24 hours following trauma. One quarter of severely …