The recognition of vitamin C is associated with a history of an unrelenting search for the
cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential …

Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and
recommended dietary intake levels are largely based these requirements. However, to …

Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …

Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and
development of humans, and their deficiency can result in serious diseases. Their …

In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …

The HIF (hypoxia-inducible factor) hydroxylases [PHDs or EGLNs (prolyl hydroxylases),
which in humans are PHD isoforms 1–3, and FIH (factor inhibiting HIF)] regulate HIF levels …

In the 1970s, P auling and C ameron reported increased survival of patients with advanced
cancer treated with high‐dose intravenous (IV) vitamin C (L‐ascorbate, ascorbic acid) …

Ascorbic acid is a multifaceted compound that can perform both antioxidant and pro-oxidant
activities in the redox reactions induced by transition metal ions, so its role in nature and …

High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-
term basis in numerous preventive and therapeutic medical applications. Instead of …

Background Ascorbic acid (AA), or Vitamin C, is most well known as a nutritional supplement
with antioxidant properties. Recently, we demonstrated that high concentrations of AA act on …