[HTML][HTML] Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus

J Blahova, M Martiniakova, M Babikova, V Kovacova… - Pharmaceuticals, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by
chronic hyperglycaemia, insulin resistance, and inefficient insulin secretion and action …

Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences

LA Gallo, EM Wright, V Vallon - Diabetes and Vascular …, 2015 - journals.sagepub.com
Traditional treatments for type 1 and type 2 diabetes are often associated with side effects,
including weight gain and hypoglycaemia that may offset the benefits of blood glucose …

Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK …

I Tzoulaki, M Molokhia, V Curcin, MP Little, CJ Millett… - Bmj, 2009 - bmj.com
Objective To investigate the risk of incident myocardial infarction, congestive heart failure,
and all cause mortality associated with prescription of oral antidiabetes drugs. Design …

Mortality risk among sulfonylureas: a systematic review and network meta-analysis

SH Simpson, J Lee, S Choi, B Vandermeer… - The lancet Diabetes & …, 2015 - thelancet.com
Background Sulfonylureas are common second-line options for management of type 2
diabetes; however, they are associated with a higher risk of cardiovascular events compared …

Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care

J Hippisley-Cox, C Coupland - bmj, 2016 - bmj.com
Objective To assess associations between risks of cardiovascular disease, heart failure, and
all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly …

Heart failure in the patient with diabetes: Epidemiology, aetiology, prognosis, therapy and the effect of glucose‐lowering medications

DSH Bell, E Goncalves - Diabetes, Obesity and Metabolism, 2019 - Wiley Online Library
In people with type 2 diabetes the frequency of heart failure (HF) is increased and mortality
from HF is higher than with non‐diabetic HF. The increased frequency of HF is attributable to …

The mechanism of action of oral antidiabetic drugs: A review of recent literature

LH Bosenberg, DG Van Zyl - Journal of Endocrinology, Metabolism …, 2008 - journals.co.za
Type 2 diabetes mellitus (DM) is a disorder that is placing an increasing burden on health
service delivery worldwide. Consequently, it has become increasingly important that …

Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics

GR Kokil, RN Veedu, GA Ramm, JB Prins… - Chemical …, 2015 - ACS Publications
Figures released in 2013 by the International Diabetes Federation (IDF) state that over 382
million individuals worldwide are affected by diabetes mellitus (DM). 1 The global …

[PDF][PDF] Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia

AC Powers, D D'Alessio - … of Therapeutics 12th edition. Edited by …, 2011 - academia.edu
Diabetes mellitus is a spectrum of metabolic disorders arising from myriad pathogenic
mechanisms, all resulting in hyperglycemia. Both genetic and environmental factors …

Combine and conquer: advantages and disadvantages of fixed‐dose combination therapy

DSH Bell - Diabetes, Obesity and Metabolism, 2013 - Wiley Online Library
The majority of patients with type 2 diabetes mellitus (T2DM) do not achieve the glycaemic
goals recommended by leading diabetes organizations using monotherapy alone, and often …