Although pancreas transplantation is increasingly being performed in an effort to provide
type 1 diabetic patients with the possibility of an insulin-injection–free existence, islet …

Pancreatic islet transplantation is an attractive option for treatment of type 1 diabetes mellitus
but maintaining long term islet function remains challenging. Mesenchymal stromal cells …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, but only a fraction of transplanted islets can survive and become engrafted, and yet …

Background. Despite the success of the Edmonton protocol for human islet transplantation,
an alternate source of islet tissue must be developed if β-cell replacement therapy is to see …

The Edmonton Protocol for treatment of type 1 diabetes requires islets from two or more
donors to achieve euglycemia in a single recipient, primarily because soon after portal …

Background. Simultaneous pancreas–kidney (SPK) transplantation carries a higher risk of
surgical complications than kidney transplantation alone. We aimed to establish the …

The ultimate goal of islet transplantation is to completely correct the diabetic state from an
unlimited donor source, without the need for chronic immunosuppressive drug therapy …

Background. With the development of the Edmonton Protocol, pancreatic islet
transplantation (PIT) now offers insulin-dependent diabetic patients metabolic stability. The …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, but only a small fraction of implanted islets become engrafted. The underlying …

Diabetes mellitus remains one of the leading causes of morbidity and mortality worldwide.
According to the Centers for Disease Control and Prevention, approximately 23.6 million …