[HTML][HTML] The discovery of insulin: an important milestone in the history of medicine

I Vecchio, C Tornali, NL Bragazzi… - Frontiers in …, 2018 - frontiersin.org
The discovery of insulin represents an authentic breakthrough, characterized, at the same
time, by contrasts, controversies and disputes among scholars, as well as by great …

Cyclodextrins based delivery systems for macro biomolecules

J Liu, X Ding, Y Fu, C Xiang, Y Yuan, Y Zhang… - European Journal of …, 2021 - Elsevier
Macro biomolecules are of vital importance in regulating the biofunctions in organisms, in
which proteins (including peptides when mentioned below) and nucleic acids (NAs) are the …

[PDF][PDF] History of diabetes: from ants to analogs

AK Das, S Shah - J Assoc Physicians India, 2011 - researchgate.net
The earliest description of diabetes was documented in the writings of Hindu scholars as
long as in 1500 BC. In 1921 the Canadian scientists Fredrick G. Banting, Charles H. Best …

[HTML][HTML] The discovery of insulin

P Diem, PH Ducluzeau, A Scheen - Diabetes Epidemiology and …, 2022 - Elsevier
The initiative for the work that led to the discovery of insulin in Toronto in 1921 came from
Frederick G. Banting. He worked under the direction of John JR Macleod in the Institute of …

Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets

P Pandya, LK Agarwal, N Gupta, S Pal - Journal of Molecular Graphics and …, 2014 - Elsevier
Vinblastine (VLB), a cytotoxic alkaloid is used extensively against various cancer types and
the crystal structure of its tubulin complex is already known. Multitarget affinity of vinblastine …

Frederick Banting's actual great idea: The role of fetal bovine islets in the discovery of insulin

JR Wright Jr - Islets, 2021 - Taylor & Francis
ABSTRACT Background: Frederick Banting approached Toronto physiology professor JJR
Macleod with a way to prevent pancreatic trypsin from destroying the pancreas' internal …

[PDF][PDF] 100 years of insulin: lifesaver, immune target, and potential remedy for prevention

AG Ziegler, T Danne, C Daniel, E Bonifacio - Med, 2021 - cell.com
In this review, we bring our personal experiences to showcase insulin from its breakthrough
discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and …

A review of piscine islet xenotransplantation using wild‐type tilapia donors and the production of transgenic tilapia expressing a “humanized” tilapia insulin

JR Wright Jr, H Yang, O Hyrtsenko, BY Xu… - …, 2014 - Wiley Online Library
Most islet xenotransplantation laboratories have focused on porcine islets, which are both
costly and difficult to isolate. Teleost (bony) fish, such as tilapia, possess macroscopically …

[HTML][HTML] The beginnings of pancreatology as a field of experimental and clinical medicine

P Ceranowicz, J Cieszkowski, Z Warzecha… - BioMed research …, 2015 - hindawi.com
This review presents the history of discoveries concerning the pancreas. In antiquity and the
Middle Ages knowledge about the anatomy of the pancreas was very limited and its function …

Winner's curse: The sad aftermath of the discovery of insulin

JR Wright Jr, EAM Gale - Diabetic Medicine, 2021 - Wiley Online Library
Every young researcher dreams of making a great discovery, but few achieve it. If they do,
success does not guarantee happiness. There is little satisfaction in discovering something if …