Development of a rat plasma and brain extracellular fluid pharmacokinetic model for bupropion and hydroxybupropion based on microdialysis sampling, and …

TIFH Cremers, G Flik, JHA Folgering, H Rollema… - Drug Metabolism and …, 2016 - ASPET
Administration of bupropion [(±)-2-(tert-butylamino)-1-(3-chlorophenyl) propan-1-one] and its
preformed active metabolite, hydroxybupropion [(±)-1-(3-chlorophenyl)-2-[(1-hydroxy-2 …