Deer antlers: the fastest growing tissue with least cancer occurrence
Deer antlers are a bony organ solely able to acquired distinct unique attributes during
evolution and all these attributes are against thus far known natural rules. One of them is as …
evolution and all these attributes are against thus far known natural rules. One of them is as …
Long-term side effects of androgen deprivation therapy in men with non-metastatic prostate cancer: a systematic literature review
SMH Alibhai, S Gogov, Z Allibhai - Critical reviews in oncology/hematology, 2006 - Elsevier
Increasing numbers of men with non-metastatic disease are receiving androgen deprivation
therapy (ADT) for a variety of indications, some of which are supported by evidence from …
therapy (ADT) for a variety of indications, some of which are supported by evidence from …
Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
LV July, M Akbari, T Zellweger, EC Jones… - The …, 2002 - Wiley Online Library
BACKGROUND Progression of prostate cancer to androgen independence (AI) results in
part from the upregulation of anti‐apoptotic genes following androgen withdrawal, and …
part from the upregulation of anti‐apoptotic genes following androgen withdrawal, and …
Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363
F Lamoureux, C Thomas, C Crafter, M Kumano… - Clinical cancer …, 2013 - AACR
Purpose: Prostate cancer development is often associated with deletion or silencing of tumor
suppressor phosphatase and tensin homolog (PTEN), a negative regulator of the …
suppressor phosphatase and tensin homolog (PTEN), a negative regulator of the …
Do older men benefit from curative therapy of localized prostate cancer?
SMH Alibhai, G Naglie, R Nam… - Journal of clinical …, 2003 - ascopubs.org
Purpose: Prior decision-analytic models are based on outdated or suboptimal efficacy,
patient preference, and comorbidity data. We estimated life expectancy (LE) and quality …
patient preference, and comorbidity data. We estimated life expectancy (LE) and quality …
[HTML][HTML] Systemic triple therapy in metastatic hormone-sensitive prostate cancer (mHSPC): ready for prime time or still to be explored?
C Thomas, M Baunacke, HHH Erb, S Füssel… - Cancers, 2021 - mdpi.com
Simple Summary Currently, a combination therapy of standard androgen deprivation
therapy (ADT) plus docetaxel or androgen receptor-axis-targeted therapy is the gold …
therapy (ADT) plus docetaxel or androgen receptor-axis-targeted therapy is the gold …
[HTML][HTML] Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition
H Tamaki, N Harashima, M Hiraki, N Arichi… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Docetaxel (DTX) is a useful chemotherapeutic drug for the treatment of hormone-refractory
prostate cancer. However, emergence of DTX resistance has been a therapeutic hurdle. In …
prostate cancer. However, emergence of DTX resistance has been a therapeutic hurdle. In …
Clusterin inhibition using OGX-011 synergistically enhances Hsp90 inhibitor activity by suppressing the heat shock response in castrate-resistant prostate cancer
F Lamoureux, C Thomas, MJ Yin, H Kuruma, E Beraldi… - Cancer research, 2011 - AACR
Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant
prostate cancer (CRPC); however, these inhibitors trigger a heat shock response that …
prostate cancer (CRPC); however, these inhibitors trigger a heat shock response that …
Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD
A Zoubeidi, A Zardan, RM Wiedmann, J Locke… - Cancer research, 2010 - AACR
Hsp27 is highly expressed in castrate-resistant prostate cancer. Although its overexpression
confers resistance to androgen ablation and chemotherapy, the mechanisms by which …
confers resistance to androgen ablation and chemotherapy, the mechanisms by which …
Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo
C Thomas, A Zoubeidi, H Kuruma, L Fazli… - Molecular cancer …, 2011 - AACR
Signal transducer and activator of transcription 5 (Stat5) plays an important role in the
transition of prostate cancer (PCa) to its castrate-resistant state. Pharmacologic targeting of …
transition of prostate cancer (PCa) to its castrate-resistant state. Pharmacologic targeting of …