The aim of this narrative review is to describe the toxicologic confounders of brain death
currently reported in the literature to offer guidance for physicians assessing brain death …

All tricyclic drugs are potentially able to cause the main acute CNS toxic syndromes of coma
and convulsions. Dosulepin (dothiepin) seems more likely to cause convulsions than other …

Tricyclic antidepressants are known to cause central nervous system depression. However,
a generalized depression of brainstem functions is rarely reported. We report a patient in …

Advances in clinical toxicology are occurring rapidly, such as defining new approaches to
clinical problem-solving, elucidating basic mechanisms of drug-induced toxicity, and …

We present a case of “complete” loss of brain stem reflexes following amitriptyline overdose,
which mimicked brain death. This case highlights the complexities associated with clinical …

The chief complaint of vertiginous symptoms can be daunting, and the differential is quite
long. Approximately 15% of patients presenting to the emergency department (ED) with …

We report the case of an 18-year-old gentleman who presented to the emergency
department following a large overdose of amitriptyline. He was comatose on admission but …

CNS is the main site of therapeutic action of TCAs and these have direct effects on the CNS.
The TCAs antidepressant effect is recognized to be the blockade of monoamine reuptake, at …

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